The experience with colorectal cancer screening in the Czech Republic: the detection at earlier stages and improved clinical outcomes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F20%3A10416658" target="_blank" >RIV/00216208:11140/20:10416658 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/20:00080274 RIV/61383082:_____/20:00000920 RIV/00216208:11110/20:10416658 RIV/65269705:_____/20:00073191 a 2 dalších

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=0RNwrlBlhR" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=0RNwrlBlhR</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.puhe.2020.05.021" target="_blank" >10.1016/j.puhe.2020.05.021</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The experience with colorectal cancer screening in the Czech Republic: the detection at earlier stages and improved clinical outcomes

Popis výsledku v původním jazyce

Objectives: Colorectal cancer (CRC) remains a major health burden. Although screening is recommended and considered beneficial, further data on its positive effects are needed for worldwide implementation. Study design: The aim of our national multicentre prospective observational study was to reveal and document clinicopathological differences in CRC diagnosed by screening and presented by disease symptoms as well as assess the efficiency of the screening programme in the Czech Republic. Methods: Between March 2013 and September 2015, a total of 265 patients were enrolled in 12 gastroenterology centres across the Czech Republic. Patients were divided into screening and symptomatic groups and compared for pathology status and clinical characteristics. Screening was defined as a primary screening colonoscopy or a colonoscopy after a positive faecal occult blood test in an averagerisk population. Results: The distribution of CRC stages was significantly (statistically and clinically) favourable in the screening group (predominance of stages 0, I and II) compared with the non-screening group (P &lt; 0.001). The presence of distant and local metastases was significantly less frequent in the screening group than in the symptomatic group (P &lt; 0.001). Patients in the screening group had a higher probability of radical surgery (RO) than those diagnosed based on symptoms (P &lt; 0.001). Systemic palliative treatment was indicated in two patients in the screening group compared with 23 patients in the non-screening group (P = 0.018). Conclusion: CRC diagnosed by screening disclosed less advanced clinicopathological characteristics and results in patients with a higher probability of radical surgery (RO) than diagnoses established based on symptoms, with subsequent management differing accordingly between both groups. These results advocate the implementation of a suitable worldwide screening programme.

Název v anglickém jazyce

The experience with colorectal cancer screening in the Czech Republic: the detection at earlier stages and improved clinical outcomes

Popis výsledku anglicky

Objectives: Colorectal cancer (CRC) remains a major health burden. Although screening is recommended and considered beneficial, further data on its positive effects are needed for worldwide implementation. Study design: The aim of our national multicentre prospective observational study was to reveal and document clinicopathological differences in CRC diagnosed by screening and presented by disease symptoms as well as assess the efficiency of the screening programme in the Czech Republic. Methods: Between March 2013 and September 2015, a total of 265 patients were enrolled in 12 gastroenterology centres across the Czech Republic. Patients were divided into screening and symptomatic groups and compared for pathology status and clinical characteristics. Screening was defined as a primary screening colonoscopy or a colonoscopy after a positive faecal occult blood test in an averagerisk population. Results: The distribution of CRC stages was significantly (statistically and clinically) favourable in the screening group (predominance of stages 0, I and II) compared with the non-screening group (P &lt; 0.001). The presence of distant and local metastases was significantly less frequent in the screening group than in the symptomatic group (P &lt; 0.001). Patients in the screening group had a higher probability of radical surgery (RO) than those diagnosed based on symptoms (P &lt; 0.001). Systemic palliative treatment was indicated in two patients in the screening group compared with 23 patients in the non-screening group (P = 0.018). Conclusion: CRC diagnosed by screening disclosed less advanced clinicopathological characteristics and results in patients with a higher probability of radical surgery (RO) than diagnoses established based on symptoms, with subsequent management differing accordingly between both groups. These results advocate the implementation of a suitable worldwide screening programme.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Public Health

ISSN

0033-3506

e-ISSN

—

Svazek periodika

185

Číslo periodika v rámci svazku

August

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

153-158

Kód UT WoS článku

000576879200050

EID výsledku v databázi Scopus

2-s2.0-85087358158