Long-term Results of Surgery for Colorectal Liver Metastases in Terms of Primary Tumour Location and Clinical Risk Factors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F20%3A10416930" target="_blank" >RIV/00216208:11140/20:10416930 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00669806:_____/20:10416930

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JcgUk6x-V5" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JcgUk6x-V5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21873/invivo.12087" target="_blank" >10.21873/invivo.12087</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Long-term Results of Surgery for Colorectal Liver Metastases in Terms of Primary Tumour Location and Clinical Risk Factors

Popis výsledku v původním jazyce

Background/Aim: The aim of the study was to evaluate the influence of primary tumour location and clinical risk factors for long-term results of surgery for colorectal liver metastases (CLMs). Patients and Methods: Overall survival (OS) and recurrence-free survival (RFS) were evaluated in 636 patients. Patients were divided by tumour location (right-/left-sided colorectal cancer: RCRC/LCRC; rectal cancer), and age, gender, number and size of CLMs, type of liver surgery and interval from primary operation were evaluated. Results: One-, 3- and 5-year OS and RFS were independent of primary tumour location (p&lt;0.59). CLM diameter was negatively associated with OS for the whole cohort (p&lt;0.002), and RCRC (p&lt;0.03) and LCRC (p&lt;0.04) groups, as well as for RFS of those with LCRC (p&lt;0.04). CLM number was negatively associated with RFS for the whole cohort (p&lt;0.0001), RCRC (p&lt;0.02), LCRC (p&lt;0.0001) and RC (p&lt;0.02). Radiofrequency ablation and combined procedures led to worse OS for the whole cohort (p&lt;0.03), and to worse RFS for the whole cohort (p&lt;0.0003) and for those with LCRC (p&lt;0.03). A shorter interval between primary colorectal cancer surgery and CLMs procedure was risky for poor OS and RFS of patients with CLMs from RCRC (p&lt;0.05), LCRC (p&lt;0.05) and RC (p&lt;0.02). Conclusion: Primary tumour location together with clinical risk factors are important for long-term results of surgery CLMs.

Název v anglickém jazyce

Long-term Results of Surgery for Colorectal Liver Metastases in Terms of Primary Tumour Location and Clinical Risk Factors

Popis výsledku anglicky

Background/Aim: The aim of the study was to evaluate the influence of primary tumour location and clinical risk factors for long-term results of surgery for colorectal liver metastases (CLMs). Patients and Methods: Overall survival (OS) and recurrence-free survival (RFS) were evaluated in 636 patients. Patients were divided by tumour location (right-/left-sided colorectal cancer: RCRC/LCRC; rectal cancer), and age, gender, number and size of CLMs, type of liver surgery and interval from primary operation were evaluated. Results: One-, 3- and 5-year OS and RFS were independent of primary tumour location (p&lt;0.59). CLM diameter was negatively associated with OS for the whole cohort (p&lt;0.002), and RCRC (p&lt;0.03) and LCRC (p&lt;0.04) groups, as well as for RFS of those with LCRC (p&lt;0.04). CLM number was negatively associated with RFS for the whole cohort (p&lt;0.0001), RCRC (p&lt;0.02), LCRC (p&lt;0.0001) and RC (p&lt;0.02). Radiofrequency ablation and combined procedures led to worse OS for the whole cohort (p&lt;0.03), and to worse RFS for the whole cohort (p&lt;0.0003) and for those with LCRC (p&lt;0.03). A shorter interval between primary colorectal cancer surgery and CLMs procedure was risky for poor OS and RFS of patients with CLMs from RCRC (p&lt;0.05), LCRC (p&lt;0.05) and RC (p&lt;0.02). Conclusion: Primary tumour location together with clinical risk factors are important for long-term results of surgery CLMs.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30212 - Surgery

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

In Vivo

ISSN

0258-851X

e-ISSN

—

Svazek periodika

34

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

GR - Řecká republika

Počet stran výsledku

11

Strana od-do

2675-2685

Kód UT WoS článku

000573472800009

EID výsledku v databázi Scopus

2-s2.0-85090178784