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FNA diagnostics of secondary malignancies in the salivary gland: Bi-institutional experience of 36 cases

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F21%3A10423021" target="_blank" >RIV/00216208:11140/21:10423021 - isvavai.cz</a>

  • Výsledek na webu

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Q1aqteRe7B" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Q1aqteRe7B</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/dc.24629" target="_blank" >10.1002/dc.24629</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    FNA diagnostics of secondary malignancies in the salivary gland: Bi-institutional experience of 36 cases

  • Popis výsledku v původním jazyce

    Fine-needle aspiration (FNA) is a key diagnostic procedure in the evaluation of salivary gland lesions. FNA is nowadays widely used in a daily clinical routine and The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) is widely accepted by the cytopathologists and endorsed by the clinicians. Primary tumors of salivary glands are rare neoplasms. According to the Global Cancer Observatory, the incidence of primary malignancies is only 0.69 new cases per 100.000 of population per year worldwide with quite remarkable differences according to the region. The crude incidence is the highest in Sweden with 4.9 new cases in comparison to the USA with 1.5 new cases per 100.000 of inhabitants in 2018.5 Such a low number gears up salivary gland carcinomas 30th in the ranking of the most frequent malignancies. Secondary malignancies of salivary glands (SMSGs) are even less common and represent about 5% of all salivary gland tumors (SGT).6,7 Surprisingly, there are significant differences in the percentage of SMSGs ranging from 10% to 44% of malignant tumors in the salivary glands in various regional studies.8,9,10 The majority of metastases are localized in the parotid gland and about 80% of metastases have their origin in the head and neck area. On the other hand, metastases in submandibular gland come in 85% of cases from the areas different from head and neck being prognostically less favorable.11 Practically every malignant tumor can send metastases into the salivary glands, but the most common is squamous cell carcinoma of the skin of the head and neck area and the upper aerodigestive tract. Less common are malignant melanomas, breast, lung, and kidney carcinomas.12 Some unusual primary metastatic tumors have been also described, namely anaplastic meningioma, hepatocellular carcinoma and metastatic carcinoid.13,14,15 Immunocytochemistry (ICC) is crucial for the correct diagnosis of metastasis in the salivary gland. It is challenging to distinguish the primary tumor without ICC. The knowledge of patient&apos;s history of malignant tumor is also a key aspect in the diagnostic work-up.6 The goal of this study was to evaluate the cytomorphological features of various secondary tumors, the spectrum of SMSGs, the role of ICC and clinical history in the diagnostics based on the experience from two tertiary care university centers in two countries.

  • Název v anglickém jazyce

    FNA diagnostics of secondary malignancies in the salivary gland: Bi-institutional experience of 36 cases

  • Popis výsledku anglicky

    Fine-needle aspiration (FNA) is a key diagnostic procedure in the evaluation of salivary gland lesions. FNA is nowadays widely used in a daily clinical routine and The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) is widely accepted by the cytopathologists and endorsed by the clinicians. Primary tumors of salivary glands are rare neoplasms. According to the Global Cancer Observatory, the incidence of primary malignancies is only 0.69 new cases per 100.000 of population per year worldwide with quite remarkable differences according to the region. The crude incidence is the highest in Sweden with 4.9 new cases in comparison to the USA with 1.5 new cases per 100.000 of inhabitants in 2018.5 Such a low number gears up salivary gland carcinomas 30th in the ranking of the most frequent malignancies. Secondary malignancies of salivary glands (SMSGs) are even less common and represent about 5% of all salivary gland tumors (SGT).6,7 Surprisingly, there are significant differences in the percentage of SMSGs ranging from 10% to 44% of malignant tumors in the salivary glands in various regional studies.8,9,10 The majority of metastases are localized in the parotid gland and about 80% of metastases have their origin in the head and neck area. On the other hand, metastases in submandibular gland come in 85% of cases from the areas different from head and neck being prognostically less favorable.11 Practically every malignant tumor can send metastases into the salivary glands, but the most common is squamous cell carcinoma of the skin of the head and neck area and the upper aerodigestive tract. Less common are malignant melanomas, breast, lung, and kidney carcinomas.12 Some unusual primary metastatic tumors have been also described, namely anaplastic meningioma, hepatocellular carcinoma and metastatic carcinoid.13,14,15 Immunocytochemistry (ICC) is crucial for the correct diagnosis of metastasis in the salivary gland. It is challenging to distinguish the primary tumor without ICC. The knowledge of patient&apos;s history of malignant tumor is also a key aspect in the diagnostic work-up.6 The goal of this study was to evaluate the cytomorphological features of various secondary tumors, the spectrum of SMSGs, the role of ICC and clinical history in the diagnostics based on the experience from two tertiary care university centers in two countries.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30109 - Pathology

Návaznosti výsledku

  • Projekt

  • Návaznosti

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2021

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Diagnostic Cytopathology

  • ISSN

    8755-1039

  • e-ISSN

  • Svazek periodika

    49

  • Číslo periodika v rámci svazku

    2

  • Stát vydavatele periodika

    US - Spojené státy americké

  • Počet stran výsledku

    11

  • Strana od-do

    241-251

  • Kód UT WoS článku

    000575007000001

  • EID výsledku v databázi Scopus

    2-s2.0-85092051419