Gene expression of cytokinesis regulators PRC1, KIF14 and CIT has no prognostic role in colorectal and pancreatic cancer
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F21%3A10426630" target="_blank" >RIV/00216208:11140/21:10426630 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00669806:_____/21:10426630 RIV/00216208:11120/21:43921775 RIV/75010330:_____/21:00013524 RIV/65269705:_____/21:00074468 a 3 dalších
Výsledek na webu
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=wmrTV-CYVo" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=wmrTV-CYVo</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3892/ol.2021.12859" target="_blank" >10.3892/ol.2021.12859</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Gene expression of cytokinesis regulators PRC1, KIF14 and CIT has no prognostic role in colorectal and pancreatic cancer
Popis výsledku v původním jazyce
Colorectal cancer is one of the most frequent cancers and pancreatic adenocarcinoma is among the most fatal and difficult to treat. New prognostic biomarkers are urgently needed to advance the treatment of these malignancies. PRC1, KIF14 and CIT play an important role in cytokinesis, strongly connected with cancer progression, and have prognostic potential. We investigated prognostic relevance of these genes for colorectal and pancreatic cancer. We followed gene expression of PRC1, KIF14 and CIT by qPCR in colorectal carcinomas and paired distant unaffected mucosa from 67 patients and tumors and paired non-neoplastic control tissues from 48 patients with pancreatic adenocarcinoma. The extent of transcript dysregulation between tumor and control tissues and between groups of patients divided by main clinical characteristics was determined. Finally, we evaluated associations of transcript levels in tumors with disease-free interval and overall survival. PRC1, KIF14 and CIT transcripts were overexpressed in tumors compared to control tissues and strongly correlated together in both patient cohorts after correction for multiple testing. However, we have not found significant associations of transcript levels in target genes with survival. Taken together, study shows overexpression and mutual correlation of the followed cytokinesis regulators with no clear prognostic value.
Název v anglickém jazyce
Gene expression of cytokinesis regulators PRC1, KIF14 and CIT has no prognostic role in colorectal and pancreatic cancer
Popis výsledku anglicky
Colorectal cancer is one of the most frequent cancers and pancreatic adenocarcinoma is among the most fatal and difficult to treat. New prognostic biomarkers are urgently needed to advance the treatment of these malignancies. PRC1, KIF14 and CIT play an important role in cytokinesis, strongly connected with cancer progression, and have prognostic potential. We investigated prognostic relevance of these genes for colorectal and pancreatic cancer. We followed gene expression of PRC1, KIF14 and CIT by qPCR in colorectal carcinomas and paired distant unaffected mucosa from 67 patients and tumors and paired non-neoplastic control tissues from 48 patients with pancreatic adenocarcinoma. The extent of transcript dysregulation between tumor and control tissues and between groups of patients divided by main clinical characteristics was determined. Finally, we evaluated associations of transcript levels in tumors with disease-free interval and overall survival. PRC1, KIF14 and CIT transcripts were overexpressed in tumors compared to control tissues and strongly correlated together in both patient cohorts after correction for multiple testing. However, we have not found significant associations of transcript levels in target genes with survival. Taken together, study shows overexpression and mutual correlation of the followed cytokinesis regulators with no clear prognostic value.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30204 - Oncology
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Oncology Letters
ISSN
1792-1074
e-ISSN
—
Svazek periodika
22
Číslo periodika v rámci svazku
2
Stát vydavatele periodika
GR - Řecká republika
Počet stran výsledku
12
Strana od-do
598
Kód UT WoS článku
000667256200001
EID výsledku v databázi Scopus
2-s2.0-85108587679