Evidence of an epidemic spread of KPC-producing Enterobacterales in Czech hospitals

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F21%3A10429973" target="_blank" >RIV/00216208:11140/21:10429973 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/21:43921841 RIV/75010330:_____/21:00013525 RIV/00064173:_____/21:N0000165

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=iqGXaOnHXU" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=iqGXaOnHXU</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-021-95285-z" target="_blank" >10.1038/s41598-021-95285-z</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Evidence of an epidemic spread of KPC-producing Enterobacterales in Czech hospitals

Popis výsledku v původním jazyce

The aim of the present study is to describe the ongoing spread of the KPC-producing strains, which is evolving to an epidemic in Czech hospitals. During the period of 2018-2019, a total of 108 KPC-producing Enterobacterales were recovered from 20 hospitals. Analysis of long-read sequencing data revealed the presence of several types of bla(KPC)-carrying plasmids; 19 out of 25 bla(KPC)-carrying plasmids could be assigned to R (n = 12), N (n = 5), C (n = 1) and P6 (n = 1) incompatibility (Inc) groups. Five of the remaining bla(KPC)-carrying plasmids were multireplicon, while one plasmid couldn&apos;t be typed. Additionally, phylogenetic analysis confirmed the spread of bla(KPC)-carrying plasmids among different clones of diverse Enterobacterales species. Our findings demonstrated that the increased prevalence of KPC-producing isolates was due to plasmids spreading among different species. In some districts, the local dissemination of IncR and IncN plasmids was observed. Additionally, the ongoing evolution of bla(KPC)-carrying plasmids, through genetic rearrangements, favours the preservation and further dissemination of these mobile genetic elements. Therefore, the situation should be monitored, and immediate infection control should be implemented in hospitals reporting KPC-producing strains.

Název v anglickém jazyce

Evidence of an epidemic spread of KPC-producing Enterobacterales in Czech hospitals

Popis výsledku anglicky

The aim of the present study is to describe the ongoing spread of the KPC-producing strains, which is evolving to an epidemic in Czech hospitals. During the period of 2018-2019, a total of 108 KPC-producing Enterobacterales were recovered from 20 hospitals. Analysis of long-read sequencing data revealed the presence of several types of bla(KPC)-carrying plasmids; 19 out of 25 bla(KPC)-carrying plasmids could be assigned to R (n = 12), N (n = 5), C (n = 1) and P6 (n = 1) incompatibility (Inc) groups. Five of the remaining bla(KPC)-carrying plasmids were multireplicon, while one plasmid couldn&apos;t be typed. Additionally, phylogenetic analysis confirmed the spread of bla(KPC)-carrying plasmids among different clones of diverse Enterobacterales species. Our findings demonstrated that the increased prevalence of KPC-producing isolates was due to plasmids spreading among different species. In some districts, the local dissemination of IncR and IncN plasmids was observed. Additionally, the ongoing evolution of bla(KPC)-carrying plasmids, through genetic rearrangements, favours the preservation and further dissemination of these mobile genetic elements. Therefore, the situation should be monitored, and immediate infection control should be implemented in hospitals reporting KPC-producing strains.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30303 - Infectious Diseases

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientific Reports

ISSN

2045-2322

e-ISSN

—

Svazek periodika

11

Číslo periodika v rámci svazku

August

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

15732

Kód UT WoS článku

000684194100003

EID výsledku v databázi Scopus

2-s2.0-85112022474