Cancer stem cells and clonal evolution in bone sarcomas

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F21%3A10442743" target="_blank" >RIV/00216208:11140/21:10442743 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/B978-0-12-821666-8.00010-4" target="_blank" >http://dx.doi.org/10.1016/B978-0-12-821666-8.00010-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/B978-0-12-821666-8.00010-4" target="_blank" >10.1016/B978-0-12-821666-8.00010-4</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cancer stem cells and clonal evolution in bone sarcomas

Popis výsledku v původním jazyce

Bone sarcomas are commonly characterized by a high degree of intratumor heterogeneity. The gaining of this diversity in cellular subpopulations involve both a clonal (epi)genetic evolution and a hierarchical organization of these clones which is governed by subsets of cells able to sustain growth. These cancer stem cells (CSCs) subpopulations are responsible for relapses and metastasis due to several stem cell-related properties that endow them with drug resistance and increased invasiveness. Different subsets of CSCs have been identified according to several stem cell-related traits and/or marker expression. Once isolated, CSCs subpopulations must demonstrate a higher tumorigenic and self-renewal potential, when compared to nonselected subpopulations. This chapter focuses on the description of CSCs subpopulations isolated from the most frequent bone sarcoma types. In addition, we recapitulate the molecular signaling that regulates the stemness state and the metastatic dissemination and discuss the dynamics that regulate clonal evolution in bone sarcomas.

Název v anglickém jazyce

Cancer stem cells and clonal evolution in bone sarcomas

Popis výsledku anglicky

Bone sarcomas are commonly characterized by a high degree of intratumor heterogeneity. The gaining of this diversity in cellular subpopulations involve both a clonal (epi)genetic evolution and a hierarchical organization of these clones which is governed by subsets of cells able to sustain growth. These cancer stem cells (CSCs) subpopulations are responsible for relapses and metastasis due to several stem cell-related properties that endow them with drug resistance and increased invasiveness. Different subsets of CSCs have been identified according to several stem cell-related traits and/or marker expression. Once isolated, CSCs subpopulations must demonstrate a higher tumorigenic and self-renewal potential, when compared to nonselected subpopulations. This chapter focuses on the description of CSCs subpopulations isolated from the most frequent bone sarcoma types. In addition, we recapitulate the molecular signaling that regulates the stemness state and the metastatic dissemination and discuss the dynamics that regulate clonal evolution in bone sarcomas.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

<a href="/cs/project/GA17-17636S" target="_blank" >GA17-17636S: Identifikace nových prognostických markerů a terapeutických cílových molekul u sarkomu měkkých tkání</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside

ISBN

978-0-12-821666-8

Počet stran výsledku

21

Strana od-do

371-391

Počet stran knihy

1078

Název nakladatele

Academic Press

Místo vydání

Amsterdam

Kód UT WoS kapitoly

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