High leptin status indicates an increased risk of mortality and heart failure in stable coronary artery disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F22%3A10446713" target="_blank" >RIV/00216208:11140/22:10446713 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00669806:_____/22:10446713 RIV/00216208:11110/22:10446713 RIV/00064190:_____/22:N0000020

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=pHt.f4VUyP" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=pHt.f4VUyP</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.numecd.2022.06.006" target="_blank" >10.1016/j.numecd.2022.06.006</a>

Jazyk výsledku

angličtina

Název v původním jazyce

High leptin status indicates an increased risk of mortality and heart failure in stable coronary artery disease

Popis výsledku v původním jazyce

Background and aims: Leptin is an adipocyte-derived peptide involved in energy homeostasis and body weight regulation. The position of leptin in cardiovascular pathophysiology remains controversial. Some studies suggest a detrimental effect of hyperleptinemia on the cardiovascular (CV) system, while others assume the role of leptin as a neutral or even protective factor. We have explored whether high leptin affects the mortality and morbidity risk in patients with stable coronary heart disease. Methods and results: We followed 975 patients &gt;=6 months after myocardial infarction or coronary revascularization in a prospective study. All-cause or cardiovascular death, non-fatal cardiovascular events (recurrent myocardial infarction, stroke, or any revascularization), and hospitalizations for heart failure (HF) we used as outcomes. High serum leptin concentrations (&gt;=18.9 ng/mL, i.e., 4th quartile) were associated with worse survival, as well as with a higher incidence of fatal vascular events or hospitalizations for HF. Even after full adjustment for potential covariates, high leptin remained to be associated with a significantly increased 5-years risk of all-cause death [Hazard risk ratio (HRR) 2.10 (95%CIs:1.29-3.42), p &lt; 0.003], CV death [HRR 2.65 (95%CIs:1.48-4.74), p &lt; 0.001], and HF hospitalization [HRR 1.95 (95% CIs:1.11-3.44), p &lt; 0.020]. In contrast, the incidence risk of non-fatal CV events was only marginally and non-significantly influenced [HRR 1.27 (95%CIs:0.76-2.13), p = 0.359]. Conclusions: High leptin concentration entails an increased risk of mortality, apparently driven by fatal CV events and future worsening of HF, on top of conventional CV risk factors and the baseline status of left ventricular function.

Název v anglickém jazyce

High leptin status indicates an increased risk of mortality and heart failure in stable coronary artery disease

Popis výsledku anglicky

Background and aims: Leptin is an adipocyte-derived peptide involved in energy homeostasis and body weight regulation. The position of leptin in cardiovascular pathophysiology remains controversial. Some studies suggest a detrimental effect of hyperleptinemia on the cardiovascular (CV) system, while others assume the role of leptin as a neutral or even protective factor. We have explored whether high leptin affects the mortality and morbidity risk in patients with stable coronary heart disease. Methods and results: We followed 975 patients &gt;=6 months after myocardial infarction or coronary revascularization in a prospective study. All-cause or cardiovascular death, non-fatal cardiovascular events (recurrent myocardial infarction, stroke, or any revascularization), and hospitalizations for heart failure (HF) we used as outcomes. High serum leptin concentrations (&gt;=18.9 ng/mL, i.e., 4th quartile) were associated with worse survival, as well as with a higher incidence of fatal vascular events or hospitalizations for HF. Even after full adjustment for potential covariates, high leptin remained to be associated with a significantly increased 5-years risk of all-cause death [Hazard risk ratio (HRR) 2.10 (95%CIs:1.29-3.42), p &lt; 0.003], CV death [HRR 2.65 (95%CIs:1.48-4.74), p &lt; 0.001], and HF hospitalization [HRR 1.95 (95% CIs:1.11-3.44), p &lt; 0.020]. In contrast, the incidence risk of non-fatal CV events was only marginally and non-significantly influenced [HRR 1.27 (95%CIs:0.76-2.13), p = 0.359]. Conclusions: High leptin concentration entails an increased risk of mortality, apparently driven by fatal CV events and future worsening of HF, on top of conventional CV risk factors and the baseline status of left ventricular function.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

<a href="/cs/project/NV17-29520A" target="_blank" >NV17-29520A: Dlouhodobé trendy sekundární prevence ICHS a predikce rizika ve vybraném vzorku české populace - česká část studie EURASPIRE V</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nutrition, Metabolism &amp; Cardiovascular Diseases

ISSN

0939-4753

e-ISSN

1590-3729

Svazek periodika

32

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

2137-2146

Kód UT WoS článku

000861111900014

EID výsledku v databázi Scopus

2-s2.0-85134245645