Fosfomycin-resistant Escherichia coli: a FosA10 case in Italy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F25%3A10497096" target="_blank" >RIV/00216208:11140/25:10497096 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=I8-IB3gsGs" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=I8-IB3gsGs</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/jacamr/dlaf052" target="_blank" >10.1093/jacamr/dlaf052</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Fosfomycin-resistant Escherichia coli: a FosA10 case in Italy

Popis výsledku v původním jazyce

BACKGROUND: FosA10-producing Enterobacterales have an extremely low incidence in Europe. PATIENTS AND METHODS: In March 2024, an 83-year-old woman, hospitalized in the Modena Province, developed an infection with fosfomycin-resistant Escherichia coli. The patient was treated with piperacillin/tazobactam and, after 10 days, the clinical picture was resolved. Fosfomycin MIC was evaluated with the reference agar dilution method and the production of FosA enzymes by phenotypic testing. Genomic characterization was assessed using long-read sequencing technology on the Sequel I platform. RESULTS: An E. coli isolate (FO_2) was collected from both blood and urine samples and showed high-level resistance to fosfomycin (MIC &gt; 128 mg/L). The resistance to fosfomycin was ascribed to the production of FosA-like enzymes by phenotypic testing. The genomic analysis pointed to a FosA10-producing E. coli ST69. The fosA10 gene was carried by a highly conjugative IncB/O/K/Z plasmid that showed relevant similarities with other globally circulating plasmids. CONCLUSIONS: The acquisition of rare fosA-like genes in clinically relevant clones is concerning and the dissemination of FosA-producing E. coli should be continuously monitored.

Název v anglickém jazyce

Fosfomycin-resistant Escherichia coli: a FosA10 case in Italy

Popis výsledku anglicky

BACKGROUND: FosA10-producing Enterobacterales have an extremely low incidence in Europe. PATIENTS AND METHODS: In March 2024, an 83-year-old woman, hospitalized in the Modena Province, developed an infection with fosfomycin-resistant Escherichia coli. The patient was treated with piperacillin/tazobactam and, after 10 days, the clinical picture was resolved. Fosfomycin MIC was evaluated with the reference agar dilution method and the production of FosA enzymes by phenotypic testing. Genomic characterization was assessed using long-read sequencing technology on the Sequel I platform. RESULTS: An E. coli isolate (FO_2) was collected from both blood and urine samples and showed high-level resistance to fosfomycin (MIC &gt; 128 mg/L). The resistance to fosfomycin was ascribed to the production of FosA-like enzymes by phenotypic testing. The genomic analysis pointed to a FosA10-producing E. coli ST69. The fosA10 gene was carried by a highly conjugative IncB/O/K/Z plasmid that showed relevant similarities with other globally circulating plasmids. CONCLUSIONS: The acquisition of rare fosA-like genes in clinically relevant clones is concerning and the dissemination of FosA-producing E. coli should be continuously monitored.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30303 - Infectious Diseases

Projekt

<a href="/cs/project/NU23J-09-00067" target="_blank" >NU23J-09-00067: Epidemiologie fosfomycinové rezistence v České republice</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JAC-Antimicrobial Resistance

ISSN

2632-1823

e-ISSN

2632-1823

Svazek periodika

7

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

dlaf052

Kód UT WoS článku

001462947500001

EID výsledku v databázi Scopus

2-s2.0-105003396260