Wireless capsule endoscopy in enteropathy induced by nonsteroidal anti-inflammatory drugs in pigs
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F10%3A10071314" target="_blank" >RIV/00216208:11150/10:10071314 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/60162694:G44__/10:00002409 RIV/00179906:_____/10:10071314
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Wireless capsule endoscopy in enteropathy induced by nonsteroidal anti-inflammatory drugs in pigs
Popis výsledku v původním jazyce
The aim of this study was to evaluate the diagnostic yield of capsule endoscopy in nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy in pigs. Indomethacin (400 mg/day) was administered orally for 10 days to eight female pigs. Afterwards, capsule endoscopy was performed, using the EndoCapsule system (OlympusOpticalCo., Tokyo, Japan). The following morning, pharmacological euthanasia and immediate autopsy were performed. Small bowel injury compatible with NSAID-induced enteropathy was observed in 7/8 animals. The most common lesions were red spots and erosions. Ulcers and small intestinal bleeding were identified sporadically. Sensitivity and specificity of capsule endoscopy were 83.3% and 95.8%, respectively. Our results indicate that wireless capsule endoscopy is a highly accurate noninvasive method for evaluation of experimental NSAID-induced enteropathy.10.1007/s10620-009-1066-z
Název v anglickém jazyce
Wireless capsule endoscopy in enteropathy induced by nonsteroidal anti-inflammatory drugs in pigs
Popis výsledku anglicky
The aim of this study was to evaluate the diagnostic yield of capsule endoscopy in nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy in pigs. Indomethacin (400 mg/day) was administered orally for 10 days to eight female pigs. Afterwards, capsule endoscopy was performed, using the EndoCapsule system (OlympusOpticalCo., Tokyo, Japan). The following morning, pharmacological euthanasia and immediate autopsy were performed. Small bowel injury compatible with NSAID-induced enteropathy was observed in 7/8 animals. The most common lesions were red spots and erosions. Ulcers and small intestinal bleeding were identified sporadically. Sensitivity and specificity of capsule endoscopy were 83.3% and 95.8%, respectively. Our results indicate that wireless capsule endoscopy is a highly accurate noninvasive method for evaluation of experimental NSAID-induced enteropathy.10.1007/s10620-009-1066-z
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FE - Ostatní obory vnitřního lékařství
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GA305%2F08%2F0535" target="_blank" >GA305/08/0535: Vliv probiotik na procesy určující farmakokinetiku léčiv</a><br>
Návaznosti
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2010
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Digestive Diseases and Sciences
ISSN
0163-2116
e-ISSN
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Svazek periodika
55
Číslo periodika v rámci svazku
9
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
7
Strana od-do
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Kód UT WoS článku
000280595500008
EID výsledku v databázi Scopus
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