Fulminant hepatitis and death associated with disseminated varicella in an immunocompromised adult from the Czech Republic caused by a wild-type clade 4 varicella-zoster virus strain

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F11%3A10104474" target="_blank" >RIV/00216208:11150/11:10104474 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G44__/11:00002424 RIV/00179906:_____/11:10104474

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S1386653210003987" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1386653210003987</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jcv.2010.09.014" target="_blank" >10.1016/j.jcv.2010.09.014</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Fulminant hepatitis and death associated with disseminated varicella in an immunocompromised adult from the Czech Republic caused by a wild-type clade 4 varicella-zoster virus strain

Popis výsledku v původním jazyce

Varicella zoster virus typically causes a benign disease in childhood called varicella (chickenpox) and can reactivate in adults as a dermatomally distributed,painful rash illness known as herpes zoster (HZ). Infection with VZV can however lead to severecomplications in immunocompromised patients that can result in hospitalization and, occasionally, death. Here we describe a patient, who acquired primary VZV infection during a 3-week-long treatment regimen with corticosteroids. The disease took a fulminant course, leading to a liver failure and severe coagulopathy. The patient died 9 days following hospital admission, despite intensive antiviral and supportive treatment. Wild-type VZV DNA was detected from multiple samples from esophagus, liver and skin. Genotypic analysis based on single nucleotide polymorphism profiles in open reading frames (ORFs) 21,22 and 50 identified this strain as a clade 4 isolate, which is typically found in tropical countries. This is the first description

Název v anglickém jazyce

Fulminant hepatitis and death associated with disseminated varicella in an immunocompromised adult from the Czech Republic caused by a wild-type clade 4 varicella-zoster virus strain

Popis výsledku anglicky

Varicella zoster virus typically causes a benign disease in childhood called varicella (chickenpox) and can reactivate in adults as a dermatomally distributed,painful rash illness known as herpes zoster (HZ). Infection with VZV can however lead to severecomplications in immunocompromised patients that can result in hospitalization and, occasionally, death. Here we describe a patient, who acquired primary VZV infection during a 3-week-long treatment regimen with corticosteroids. The disease took a fulminant course, leading to a liver failure and severe coagulopathy. The patient died 9 days following hospital admission, despite intensive antiviral and supportive treatment. Wild-type VZV DNA was detected from multiple samples from esophagus, liver and skin. Genotypic analysis based on single nucleotide polymorphism profiles in open reading frames (ORFs) 21,22 and 50 identified this strain as a clade 4 isolate, which is typically found in tropical countries. This is the first description

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FN - Epidemiologie, infekční nemoci a klinická imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP304%2F10%2F1161" target="_blank" >GAP304/10/1161: Role buněčných proteinů asociovaných s viry v patogenezi dysfunkce T lymfocytů</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Clinical Virology

ISSN

1386-6532

e-ISSN

—

Svazek periodika

50

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

4

Strana od-do

72-75

Kód UT WoS článku

000286094300016

EID výsledku v databázi Scopus

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