The effect of oral sodium loading and saline infusion on direct active renin in healthy volunteers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F11%3A10108580" target="_blank" >RIV/00216208:11150/11:10108580 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/11:10108580

Výsledek na webu

<a href="http://86.120.250.122:8082/2011/numarul1/fulltext/The%20Effect%20of%20Oral%20Sodium%20Loading%20and%20Saline%20Infusion%20on%20Direct%20Active%20Renin%20in%20Healthy%20Volunteers.pdf" target="_blank" >http://86.120.250.122:8082/2011/numarul1/fulltext/The%20Effect%20of%20Oral%20Sodium%20Loading%20and%20Saline%20Infusion%20on%20Direct%20Active%20Renin%20in%20Healthy%20Volunteers.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4183/aeb.2011.33" target="_blank" >10.4183/aeb.2011.33</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The effect of oral sodium loading and saline infusion on direct active renin in healthy volunteers

Popis výsledku v původním jazyce

In patients with suspected primary aldosteronism (PA), the aldosteroneto-renin ratio (ARR) is the most frequently recommended screening test. Further evaluation is based on hormonal changes during volume expansion. Both analyses are critically dependenton an accurate estimation of renin concentration. Direct active renin (DAR) is a novel laboratory technique used for plasma renin assessment. The objective of this study was to evaluate DAR for use in PA diagnostic work-ups. The study enrolled 69 healthyvolunteers. Blood sampling was conducted before and after an increase in oral salt intake. Furthermore, a subset of 32 individuals uderwent a saline infusion suppression terst. DAR and serum aldosterone were measured in all blood samples. To calculate the ARR, serum aldosterone and DAR were expressed in ng/L. ARR values (median (range); 97,5 percentile) associated with normal and elevated oral salt intake were 8.4 (0.6-37.7); 26.3, and 6.8 (1.1-37.7); 19.6, respectively. DAR and serum a

Název v anglickém jazyce

The effect of oral sodium loading and saline infusion on direct active renin in healthy volunteers

Popis výsledku anglicky

In patients with suspected primary aldosteronism (PA), the aldosteroneto-renin ratio (ARR) is the most frequently recommended screening test. Further evaluation is based on hormonal changes during volume expansion. Both analyses are critically dependenton an accurate estimation of renin concentration. Direct active renin (DAR) is a novel laboratory technique used for plasma renin assessment. The objective of this study was to evaluate DAR for use in PA diagnostic work-ups. The study enrolled 69 healthyvolunteers. Blood sampling was conducted before and after an increase in oral salt intake. Furthermore, a subset of 32 individuals uderwent a saline infusion suppression terst. DAR and serum aldosterone were measured in all blood samples. To calculate the ARR, serum aldosterone and DAR were expressed in ng/L. ARR values (median (range); 97,5 percentile) associated with normal and elevated oral salt intake were 8.4 (0.6-37.7); 26.3, and 6.8 (1.1-37.7); 19.6, respectively. DAR and serum a

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Endocrinology

ISSN

1841-0987

e-ISSN

—

Svazek periodika

7

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

RO - Rumunsko

Počet stran výsledku

6

Strana od-do

33-38

Kód UT WoS článku

000289007600004

EID výsledku v databázi Scopus

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