The Effect of Mud-Bath Therapy on Bone Status in Rats During Adjuvant Subchronic Arthritis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F12%3A10130777" target="_blank" >RIV/00216208:11150/12:10130777 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The Effect of Mud-Bath Therapy on Bone Status in Rats During Adjuvant Subchronic Arthritis

Popis výsledku v původním jazyce

We studied influence of mud-bath on bone status in male Wistar rats with subchronic arthritis. Arthritis was induced by 2 subplantar injections of Freund's adjuvans with heat-killed Streptoccocus pyogenes. Groups: intact (int) on chippings; (con) arthritis on chippings; (san38) arthritis on hot sand; (mu38) arthritis on hot mud; (mu21) arthritis on mild mud. Bone mineral density (BMD, g/cm2) was measured by dual energy X-ray absorptiometry and femurs were tested biomechanically. Bone markers osteocalcin, PINP and CTX were analysed in bone. The hot bath appears indifferent in relation to osteoporosis, while cold mud-bath shows good effect on bone metabolism. The cold mud-baths help to reduce arthritic inflammation and pain and thereby lead to higher mobility with positive consequence on bone. BMD of right femur decreased vs. left in san38 (p=0.030) and mu38. Fracture load of right/left femur (N) decreased in experimental groups, significantly in san38. Fracture threshold of neck decreas

Název v anglickém jazyce

The Effect of Mud-Bath Therapy on Bone Status in Rats During Adjuvant Subchronic Arthritis

Popis výsledku anglicky

We studied influence of mud-bath on bone status in male Wistar rats with subchronic arthritis. Arthritis was induced by 2 subplantar injections of Freund's adjuvans with heat-killed Streptoccocus pyogenes. Groups: intact (int) on chippings; (con) arthritis on chippings; (san38) arthritis on hot sand; (mu38) arthritis on hot mud; (mu21) arthritis on mild mud. Bone mineral density (BMD, g/cm2) was measured by dual energy X-ray absorptiometry and femurs were tested biomechanically. Bone markers osteocalcin, PINP and CTX were analysed in bone. The hot bath appears indifferent in relation to osteoporosis, while cold mud-bath shows good effect on bone metabolism. The cold mud-baths help to reduce arthritic inflammation and pain and thereby lead to higher mobility with positive consequence on bone. BMD of right femur decreased vs. left in san38 (p=0.030) and mu38. Fracture load of right/left femur (N) decreased in experimental groups, significantly in san38. Fracture threshold of neck decreas

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Kralove

ISSN

1211-4286

e-ISSN

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Svazek periodika

55

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

133-137

Kód UT WoS článku

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EID výsledku v databázi Scopus

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