Proteomics and bioinformatics analysis reveal underlying pathways of infection associated histologic chorioamnionitis in pPROM

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F13%3A10130773" target="_blank" >RIV/00216208:11150/13:10130773 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/13:10130773 RIV/60162694:G44__/13:43874979

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0143400412004638" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0143400412004638</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.placenta.2012.11.028" target="_blank" >10.1016/j.placenta.2012.11.028</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Proteomics and bioinformatics analysis reveal underlying pathways of infection associated histologic chorioamnionitis in pPROM

Popis výsledku v původním jazyce

Introduction: The presence of microbial invasion of the amniotic cavity (MIAC) and histological chorioamnionitis (HCA) is associated with adverse neonatal outcomes in pregnancies complicated by preterm prelabor rupture of membranes (pPROM). Therefore, there is an urgent need to identify new biomarkers revealing these conditions. The objective of this study is to identify possible biomarkers and their underlying biofunctions in pPROM pregnancies with and without MIAC and HCA. Methods: A total of 72 womenwith pPROM were recruited. Only women with both MIAC and HCA (n 1/4 19) and all women without these complications (n 1/4 19) having the same range of gestational ages at sampling were included in the study. Samples of amniotic fluid were obtained by transabdominal amniocentesis, processed and analyzed using quantitative shotgun proteomics. Ingenuity pathway analysis was used to identify molecular networks that involve altered proteins. Results: Network interaction identified by ingenuit

Název v anglickém jazyce

Proteomics and bioinformatics analysis reveal underlying pathways of infection associated histologic chorioamnionitis in pPROM

Popis výsledku anglicky

Introduction: The presence of microbial invasion of the amniotic cavity (MIAC) and histological chorioamnionitis (HCA) is associated with adverse neonatal outcomes in pregnancies complicated by preterm prelabor rupture of membranes (pPROM). Therefore, there is an urgent need to identify new biomarkers revealing these conditions. The objective of this study is to identify possible biomarkers and their underlying biofunctions in pPROM pregnancies with and without MIAC and HCA. Methods: A total of 72 womenwith pPROM were recruited. Only women with both MIAC and HCA (n 1/4 19) and all women without these complications (n 1/4 19) having the same range of gestational ages at sampling were included in the study. Samples of amniotic fluid were obtained by transabdominal amniocentesis, processed and analyzed using quantitative shotgun proteomics. Ingenuity pathway analysis was used to identify molecular networks that involve altered proteins. Results: Network interaction identified by ingenuit

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FK - Gynekologie a porodnictví

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Placenta

ISSN

0143-4004

e-ISSN

—

Svazek periodika

34

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

155-161

Kód UT WoS článku

000314857100011

EID výsledku v databázi Scopus

—