Selenite-Mediated Cellular Stress, Apoptosis and Autophagy in Colon Cancer Cells
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F13%3A10173576" target="_blank" >RIV/00216208:11150/13:10173576 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Selenite-Mediated Cellular Stress, Apoptosis and Autophagy in Colon Cancer Cells
Popis výsledku v původním jazyce
Colorectal carcinoma (CRC) continues to be a major problem in developed countries, and successful preventive strategies concerning this malignancy are still missing. Sodium selenite has emerged as a potential chemopreventive agent due to a number of specials effects which produce colon cancer cells, regardless of their status. Selenite has been able to decrease cell proliferation and induce cytotoxicity by several mechanisms. These include direct inhibition of several molecular targets, signaling pathways (p53-dependent, mTOR, p38, JNK), or subcellular compartments (mitochondria), as well as activation of apoptosis and autophagy. Our data combined with results of studies conducted by other reserarch groups demonstrate a close connection between selenite-induced oxidative stress and apoptosis. In addition, the concurrent existence of autophagy and apoptosis in selenite-treated cells, their mutual relationship, and diverse regulatory patterns upon differing p53 status of cells suggest a
Název v anglickém jazyce
Selenite-Mediated Cellular Stress, Apoptosis and Autophagy in Colon Cancer Cells
Popis výsledku anglicky
Colorectal carcinoma (CRC) continues to be a major problem in developed countries, and successful preventive strategies concerning this malignancy are still missing. Sodium selenite has emerged as a potential chemopreventive agent due to a number of specials effects which produce colon cancer cells, regardless of their status. Selenite has been able to decrease cell proliferation and induce cytotoxicity by several mechanisms. These include direct inhibition of several molecular targets, signaling pathways (p53-dependent, mTOR, p38, JNK), or subcellular compartments (mitochondria), as well as activation of apoptosis and autophagy. Our data combined with results of studies conducted by other reserarch groups demonstrate a close connection between selenite-induced oxidative stress and apoptosis. In addition, the concurrent existence of autophagy and apoptosis in selenite-treated cells, their mutual relationship, and diverse regulatory patterns upon differing p53 status of cells suggest a
Klasifikace
Druh
C - Kapitola v odborné knize
CEP obor
EB - Genetika a molekulární biologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název knihy nebo sborníku
Autophagy: cancer, other pathologies, inflammation, immunity infection, and aging. Volume 1, Molecular Mechanisms
ISBN
978-0-12-405530-8
Počet stran výsledku
13
Strana od-do
221-233
Počet stran knihy
329
Název nakladatele
Elsevier
Místo vydání
Amsterdam
Kód UT WoS kapitoly
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