Ferns and Lycopods - A Potential Treasury of Anticancer Agents but Also a Carcinogenic Hazard

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F14%3A10188909" target="_blank" >RIV/00216208:11150/14:10188909 - isvavai.cz</a>

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1002/ptr.5070/abstract;jsessionid=CFBFCEBD90D4B8C4FE250B12CF3FC616.f04t03" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/ptr.5070/abstract;jsessionid=CFBFCEBD90D4B8C4FE250B12CF3FC616.f04t03</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ptr.5070" target="_blank" >10.1002/ptr.5070</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Ferns and Lycopods - A Potential Treasury of Anticancer Agents but Also a Carcinogenic Hazard

Popis výsledku v původním jazyce

Many species of seedless vascular plants-ferns and lycopods-have been used as food and folk medicine since ancient times. Some of them have become the focus of intensive research concerning their anticancer properties. Studies on the anticancer effect ofcrude extracts are being increasingly replaced by bioactivity-guided fractionation, as well as detailed assessment of the mechanism of action. Numerous compounds-especially flavonoids such as amentoflavone and protoapigenone, and also simpler phenolic compounds, steroids, alkaloids and terpenoids- were isolated and found to be cytotoxic, particularly pro-apoptotic, or to induce cell cycle arrest in cancer cell lines in vitro. In in vivo experiments, some fern-derived compounds inhibited tumour growth with little toxicity. On the other hand, many ferns-not only the well-known Bracken (Pteridium)-may pose a significant hazard to human health due to the fact that they contain carcinogenic sesquiterpenoids and their analogues. The objectiv

Název v anglickém jazyce

Ferns and Lycopods - A Potential Treasury of Anticancer Agents but Also a Carcinogenic Hazard

Popis výsledku anglicky

Many species of seedless vascular plants-ferns and lycopods-have been used as food and folk medicine since ancient times. Some of them have become the focus of intensive research concerning their anticancer properties. Studies on the anticancer effect ofcrude extracts are being increasingly replaced by bioactivity-guided fractionation, as well as detailed assessment of the mechanism of action. Numerous compounds-especially flavonoids such as amentoflavone and protoapigenone, and also simpler phenolic compounds, steroids, alkaloids and terpenoids- were isolated and found to be cytotoxic, particularly pro-apoptotic, or to induce cell cycle arrest in cancer cell lines in vitro. In in vivo experiments, some fern-derived compounds inhibited tumour growth with little toxicity. On the other hand, many ferns-not only the well-known Bracken (Pteridium)-may pose a significant hazard to human health due to the fact that they contain carcinogenic sesquiterpenoids and their analogues. The objectiv

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Phytotherapy Research

ISSN

0951-418X

e-ISSN

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Svazek periodika

28

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

798-810

Kód UT WoS článku

000337575400002

EID výsledku v databázi Scopus

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