Experimental models of non-alcoholic fatty liver disease in rats
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F14%3A10271877" target="_blank" >RIV/00216208:11150/14:10271877 - isvavai.cz</a>
Výsledek na webu
<a href="http://www.wjgnet.com/1007-9327/pdf/v20/i26/8364.pdf" target="_blank" >http://www.wjgnet.com/1007-9327/pdf/v20/i26/8364.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3748/wjg.v20.i26.8364" target="_blank" >10.3748/wjg.v20.i26.8364</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Experimental models of non-alcoholic fatty liver disease in rats
Popis výsledku v původním jazyce
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the Western world, and it persists at a high prevalence. The pathogenesis of NAFLD is closely related to the metabolic syndrome and insulin resistance. Understanding the pathophysiology and treatment of NAFLD in humans has currently been limited by the lack of satisfactory animal models. The ideal animal model for NAFLD should reflect all aspects of the intricate etiopathogenesis of human NAFLD and the typical histological findings of its different stages. This paper reviews the widely used experimental models of NAFLD in rats. We discuss nutritional, genetic and combined models of NAFLD and their pros and cons. The choice of a suitable animal model for this disease while respecting its limitations may help to improve the understanding of its complex pathogenesis and to discover appropriate therapeutic strategies.
Název v anglickém jazyce
Experimental models of non-alcoholic fatty liver disease in rats
Popis výsledku anglicky
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the Western world, and it persists at a high prevalence. The pathogenesis of NAFLD is closely related to the metabolic syndrome and insulin resistance. Understanding the pathophysiology and treatment of NAFLD in humans has currently been limited by the lack of satisfactory animal models. The ideal animal model for NAFLD should reflect all aspects of the intricate etiopathogenesis of human NAFLD and the typical histological findings of its different stages. This paper reviews the widely used experimental models of NAFLD in rats. We discuss nutritional, genetic and combined models of NAFLD and their pros and cons. The choice of a suitable animal model for this disease while respecting its limitations may help to improve the understanding of its complex pathogenesis and to discover appropriate therapeutic strategies.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
ED - Fyziologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
World Journal of Gastroenterology
ISSN
1007-9327
e-ISSN
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Svazek periodika
20
Číslo periodika v rámci svazku
26
Stát vydavatele periodika
CN - Čínská lidová republika
Počet stran výsledku
13
Strana od-do
8364-8376
Kód UT WoS článku
000339389500004
EID výsledku v databázi Scopus
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