Prothrombotic changes due to an increase in thyroid hormone levels

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10293568" target="_blank" >RIV/00216208:11150/15:10293568 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/15:10293568

Výsledek na webu

<a href="http://dx.doi.org/10.1530/EJE-14-0801" target="_blank" >http://dx.doi.org/10.1530/EJE-14-0801</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1530/EJE-14-0801" target="_blank" >10.1530/EJE-14-0801</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Prothrombotic changes due to an increase in thyroid hormone levels

Popis výsledku v původním jazyce

Objective With increasing free thyroxine levels, a gradually rising risk of venous thromboembolism has been described in case-control studies. However, reports on the influence of thyroid hormones on haemostasis, while suggesting a hypercoagulable statein thyrotoxicosis, have often been inconclusive. The present study evaluates multiple markers of haemostasis and fibrinolysis in a paired design, making it more sensitive to changes in thyroid hormone levels. Design We analysed multiple variables in patients who shifted from severe hypothyroidism to mild hyperthyroidism during thyroid cancer treatment. Those with possible residual disease were excluded. Methods Ninety patients following total thyroidectomy were tested on two occasions: (a) before radioiodine remnant ablation and (b) 6 weeks later, on levothyroxine suppression treatment, and the results were compared using the Wilcoxon test for paired data. Results During levothyroxine treatment, significant increases (all p<0.001) in fi

Název v anglickém jazyce

Prothrombotic changes due to an increase in thyroid hormone levels

Popis výsledku anglicky

Objective With increasing free thyroxine levels, a gradually rising risk of venous thromboembolism has been described in case-control studies. However, reports on the influence of thyroid hormones on haemostasis, while suggesting a hypercoagulable statein thyrotoxicosis, have often been inconclusive. The present study evaluates multiple markers of haemostasis and fibrinolysis in a paired design, making it more sensitive to changes in thyroid hormone levels. Design We analysed multiple variables in patients who shifted from severe hypothyroidism to mild hyperthyroidism during thyroid cancer treatment. Those with possible residual disease were excluded. Methods Ninety patients following total thyroidectomy were tested on two occasions: (a) before radioiodine remnant ablation and (b) 6 weeks later, on levothyroxine suppression treatment, and the results were compared using the Wilcoxon test for paired data. Results During levothyroxine treatment, significant increases (all p<0.001) in fi

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

—

Projekt

<a href="/cs/project/NT13535" target="_blank" >NT13535: Vztah hormonů štítné žlázy k hemostáze a hemokoagulaci u pacientů s karcinomy štítné žlázy</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Endocrinology

ISSN

0804-4643

e-ISSN

—

Svazek periodika

172

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

537-542

Kód UT WoS článku

000354626400009

EID výsledku v databázi Scopus

2-s2.0-84929511579