Clear cell myoepithelial carcinoma of salivary glands showing EWSR1 rearrangement. Molecular analysis of 94 salivary gland carcinomas with prominent clear cell component

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10294673" target="_blank" >RIV/00216208:11150/15:10294673 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/15:10294673 RIV/00216208:11140/15:10294673

Výsledek na webu

<a href="http://dx.doi.org/10.1097/PAS.0000000000000364" target="_blank" >http://dx.doi.org/10.1097/PAS.0000000000000364</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/PAS.0000000000000364" target="_blank" >10.1097/PAS.0000000000000364</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Clear cell myoepithelial carcinoma of salivary glands showing EWSR1 rearrangement. Molecular analysis of 94 salivary gland carcinomas with prominent clear cell component

Popis výsledku v původním jazyce

This study examines the presence of the EWSR1 rearrangement in a variety of clear cell salivary gland carcinomas with myoepithelial differentiation. A total of 94 salivary gland carcinomas with a prominent clear cell component included 51 cases of clearcell myoepithelial carcinomas de novo (CCMC), 21 cases of CCMCs ex pleomorphic adenoma (CCMCexPA), 11 cases of epithelial-myoepithelial carcinoma (EMC), 6 cases of EMC with solid clear cell overgrowth, and 5 cases of hyalinizingclear cell carcinoma of minor salivary glands. In addition, 10 cases of myoepithelial carcinomas devoid of clear cell change and 12 cases of benign myoepithelioma were included as well. All the tumors in this spectrum were reviewed, reclassified, and tested by fluorescence in situ hybridization (FISH) for the EWSR1 rearrangement using the Probe Vysis EWSR1 Break Apart FISH Probe Kit. The EWSR1 rearrangement was detected in 20 of 51 (39%) cases of CCMC, in 5 of 21 (24%) cases of CCMCexPA, in 1 of 11 (9%) cases of

Název v anglickém jazyce

Clear cell myoepithelial carcinoma of salivary glands showing EWSR1 rearrangement. Molecular analysis of 94 salivary gland carcinomas with prominent clear cell component

Popis výsledku anglicky

This study examines the presence of the EWSR1 rearrangement in a variety of clear cell salivary gland carcinomas with myoepithelial differentiation. A total of 94 salivary gland carcinomas with a prominent clear cell component included 51 cases of clearcell myoepithelial carcinomas de novo (CCMC), 21 cases of CCMCs ex pleomorphic adenoma (CCMCexPA), 11 cases of epithelial-myoepithelial carcinoma (EMC), 6 cases of EMC with solid clear cell overgrowth, and 5 cases of hyalinizingclear cell carcinoma of minor salivary glands. In addition, 10 cases of myoepithelial carcinomas devoid of clear cell change and 12 cases of benign myoepithelioma were included as well. All the tumors in this spectrum were reviewed, reclassified, and tested by fluorescence in situ hybridization (FISH) for the EWSR1 rearrangement using the Probe Vysis EWSR1 Break Apart FISH Probe Kit. The EWSR1 rearrangement was detected in 20 of 51 (39%) cases of CCMC, in 5 of 21 (24%) cases of CCMCexPA, in 1 of 11 (9%) cases of

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

—

Projekt

<a href="/cs/project/NT13701" target="_blank" >NT13701: Exprese vaskulárního endoteliálního růstového faktoru VEGF-C/D a její význam pro lymfangioneogenezu, uzlinové metastázování a prognózu karcinomů slinných žláz.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American Journal of Surgical Pathology

ISSN

0147-5185

e-ISSN

—

Svazek periodika

39

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

338-348

Kód UT WoS článku

000349803400007

EID výsledku v databázi Scopus

2-s2.0-84924041969