Ammonia and amino acid profiles in liver cirrhosis: Effects of variables leading to hepatic encephalopathy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10295083" target="_blank" >RIV/00216208:11150/15:10295083 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0899900714001506" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0899900714001506</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.nut.2014.03.016" target="_blank" >10.1016/j.nut.2014.03.016</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Ammonia and amino acid profiles in liver cirrhosis: Effects of variables leading to hepatic encephalopathy

Popis výsledku v původním jazyce

In the article is demonstrated that the main source of ammonia in cirrhotic subjects is activated breakdown of glutamine (GLN) in enterocytes and the kidneys and the main source of GLN is ammonia detoxification to GLN in the brain and skeletal muscle. The branched-chain amino acids (BCAA; valine, leucine, and isoleucine) decrease due to activated GLN synthesis in muscle. Aromatic amino acids (AAA; phenylalanine, tyrosine, and tryptophan) and methionine increase due to portosystemic shunts and reduced ability of diseased liver. It is concluded that (1) neither ammonia nor amino acid concentrations correlate closely with the severity of liver disease; (2) BCAA/AAA ratio could be used as a good index of liver impairment and for early detection of derangements in amino acid metabolism; and (3) variables potentially leading to overt encephalopathy exert substantial but uneven effects.

Název v anglickém jazyce

Ammonia and amino acid profiles in liver cirrhosis: Effects of variables leading to hepatic encephalopathy

Popis výsledku anglicky

In the article is demonstrated that the main source of ammonia in cirrhotic subjects is activated breakdown of glutamine (GLN) in enterocytes and the kidneys and the main source of GLN is ammonia detoxification to GLN in the brain and skeletal muscle. The branched-chain amino acids (BCAA; valine, leucine, and isoleucine) decrease due to activated GLN synthesis in muscle. Aromatic amino acids (AAA; phenylalanine, tyrosine, and tryptophan) and methionine increase due to portosystemic shunts and reduced ability of diseased liver. It is concluded that (1) neither ammonia nor amino acid concentrations correlate closely with the severity of liver disease; (2) BCAA/AAA ratio could be used as a good index of liver impairment and for early detection of derangements in amino acid metabolism; and (3) variables potentially leading to overt encephalopathy exert substantial but uneven effects.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nutrition

ISSN

0899-9007

e-ISSN

—

Svazek periodika

31

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

14-20

Kód UT WoS článku

000346685600002

EID výsledku v databázi Scopus

2-s2.0-84922252345