Comparative study of various subpopulations of cytotoxic cells in blood and ascites from patients with ovarian carcinoma
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10312145" target="_blank" >RIV/00216208:11150/15:10312145 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00179906:_____/15:10312145
Výsledek na webu
<a href="http://www.termedia.pl/Journal/-3/Streszczenie-25814" target="_blank" >http://www.termedia.pl/Journal/-3/Streszczenie-25814</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5114/wo.2015.54388" target="_blank" >10.5114/wo.2015.54388</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Comparative study of various subpopulations of cytotoxic cells in blood and ascites from patients with ovarian carcinoma
Popis výsledku v původním jazyce
A number of observations indicate that the immune system plays a significant role in patients with epithelial ovarian cancer (EOC). In case of EOC the prognostic significance of tumour infiltrating lymphocytes, (TILs) has not been obviously explained yet. The aim is to determine the phenotype and activation molecule of cytotoxic T cells and NK cells subpopulations and to compare their representation in malignant ascites and peripheral blood (PBL) in patients with ovarian cancer. The cytotoxic cells taken from blood samples of the cubital vein and malignant ascites were obtained from 53 patients with EOC. Their surface and activation characteristics were determined by means of a flow cytometer. Immunophenotype multiparametric analysis of PBL and TILs was carried out. CD3+ T lymphocytes were the main population of TILs (75.9%) and PBL (70.9%). The number of activating T cells was significantly higher in TILs, CD3+/69+ 6.7% vs.0.8% (p<0.001). The representation of (CD3-/16+56+) NK cells i
Název v anglickém jazyce
Comparative study of various subpopulations of cytotoxic cells in blood and ascites from patients with ovarian carcinoma
Popis výsledku anglicky
A number of observations indicate that the immune system plays a significant role in patients with epithelial ovarian cancer (EOC). In case of EOC the prognostic significance of tumour infiltrating lymphocytes, (TILs) has not been obviously explained yet. The aim is to determine the phenotype and activation molecule of cytotoxic T cells and NK cells subpopulations and to compare their representation in malignant ascites and peripheral blood (PBL) in patients with ovarian cancer. The cytotoxic cells taken from blood samples of the cubital vein and malignant ascites were obtained from 53 patients with EOC. Their surface and activation characteristics were determined by means of a flow cytometer. Immunophenotype multiparametric analysis of PBL and TILs was carried out. CD3+ T lymphocytes were the main population of TILs (75.9%) and PBL (70.9%). The number of activating T cells was significantly higher in TILs, CD3+/69+ 6.7% vs.0.8% (p<0.001). The representation of (CD3-/16+56+) NK cells i
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EE - Mikrobiologie, virologie
OECD FORD obor
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Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Wspolczesna Onkologia
ISSN
1428-2526
e-ISSN
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Svazek periodika
19
Číslo periodika v rámci svazku
4
Stát vydavatele periodika
PL - Polská republika
Počet stran výsledku
10
Strana od-do
290-299
Kód UT WoS článku
—
EID výsledku v databázi Scopus
2-s2.0-84942605792