Markers of Endothelial Activation in Preeclampsia

Kód výsledku v IS VaVaI

RIV/00216208:11150/15:10312493 - isvavai.cz

Nalezeny alternativní kódy

RIV/00843989:_____/15:E0104894 RIV/61989592:15110/15:33154136 RIV/61989592:15120/15:33154136

Výsledek na webu

http://dx.doi.org/10.7754/Clin.Lab.2014.140521

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Markers of Endothelial Activation in Preeclampsia

Popis výsledku v původním jazyce

Background: The study aimed at finding a laboratory approach to detect endothelial damage in normal pregnancy as well as in pregnancy complicated by preeclampsia using selected markers of endothelial activation. Materials: A total of 403 healthy pregnantwomen without a history of deep vein thrombosis and/or hypertension were prospectively studied. From all women, venous blood was collected before the end of the 1st trimester, between weeks 24 and 28 of gestation, and in the 3rd trimester (weeks 34 - 36). Assays of tissue plasminogen activator, plasminogen activator inhibitor-1, von Willebrand factor activity and antigen, thrombomodulin, endothelial protein C receptor, and endothelial microparticles activated by TF were performed. Results: When comparing women who developed preeclampsia during pregnancy (the average levels were 23.41 mu g/L, 34.33 mu g/L, and 53.56 mu g/L in the 1st, 2nd, and 3rd trimesters, respectively) with healthy pregnant women (the average levels were 19.05 mu g/

Název v anglickém jazyce

Markers of Endothelial Activation in Preeclampsia

Popis výsledku anglicky

Background: The study aimed at finding a laboratory approach to detect endothelial damage in normal pregnancy as well as in pregnancy complicated by preeclampsia using selected markers of endothelial activation. Materials: A total of 403 healthy pregnantwomen without a history of deep vein thrombosis and/or hypertension were prospectively studied. From all women, venous blood was collected before the end of the 1st trimester, between weeks 24 and 28 of gestation, and in the 3rd trimester (weeks 34 - 36). Assays of tissue plasminogen activator, plasminogen activator inhibitor-1, von Willebrand factor activity and antigen, thrombomodulin, endothelial protein C receptor, and endothelial microparticles activated by TF were performed. Results: When comparing women who developed preeclampsia during pregnancy (the average levels were 23.41 mu g/L, 34.33 mu g/L, and 53.56 mu g/L in the 1st, 2nd, and 3rd trimesters, respectively) with healthy pregnant women (the average levels were 19.05 mu g/

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FK - Gynekologie a porodnictví

OECD FORD obor

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Projekt

NT14394: Vliv exprese tkáňového faktoru na vznik těhotenských komplikací

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Laboratory

ISSN

1433-6510

e-ISSN

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Svazek periodika

61

Číslo periodika v rámci svazku

1-2

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

8

Strana od-do

39-46

Kód UT WoS článku

000352681100006

EID výsledku v databázi Scopus

2-s2.0-84924767471