The Effect of LDL-Apheresis and Rheohaemapheresis Treatment on Vitamin E

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10312538" target="_blank" >RIV/00216208:11150/15:10312538 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61389030:_____/15:00446930 RIV/00216208:11160/15:10312538 RIV/00179906:_____/15:10312538

Výsledek na webu

<a href="http://www.jstage.jst.go.jp/article/jnsv/61/2/61_105/_article" target="_blank" >http://www.jstage.jst.go.jp/article/jnsv/61/2/61_105/_article</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3177/jnsv.61.105" target="_blank" >10.3177/jnsv.61.105</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The Effect of LDL-Apheresis and Rheohaemapheresis Treatment on Vitamin E

Popis výsledku v původním jazyce

Lipid apheresis (extracorporeal lipoprotein elimination) is administered to patients with familial hypercholesterolemia who fail to respond to standard therapy. The nature of the treatment process raises the suspicion that it decreases not only cholesterol but also antioxidants. A group of 12 patients (average age 47 +/- 17 y, 4 homozygous and 8 heterozygous individuals) with familial hypercholesterolemia treated by LDL-apheresis or rheohaemapheresis for 3-12 y was included in the study. In addition tocholesterol and triacylglycerol levels, vitamin E and vitamin A and also other markers of antioxidant activity were investigated. Nevertheless, the most important determined parameter was the vitamin E/cholesterol ratio in serum and lipoproteins. The results indicate that both extracorporeal elimination methods are effective and suitable ways to treat severe familial hypercholesterolemia, as the LDL fraction of cholesterol decreased by approximately 77% and 66% following LDL-apheresis an

Název v anglickém jazyce

The Effect of LDL-Apheresis and Rheohaemapheresis Treatment on Vitamin E

Popis výsledku anglicky

Lipid apheresis (extracorporeal lipoprotein elimination) is administered to patients with familial hypercholesterolemia who fail to respond to standard therapy. The nature of the treatment process raises the suspicion that it decreases not only cholesterol but also antioxidants. A group of 12 patients (average age 47 +/- 17 y, 4 homozygous and 8 heterozygous individuals) with familial hypercholesterolemia treated by LDL-apheresis or rheohaemapheresis for 3-12 y was included in the study. In addition tocholesterol and triacylglycerol levels, vitamin E and vitamin A and also other markers of antioxidant activity were investigated. Nevertheless, the most important determined parameter was the vitamin E/cholesterol ratio in serum and lipoproteins. The results indicate that both extracorporeal elimination methods are effective and suitable ways to treat severe familial hypercholesterolemia, as the LDL fraction of cholesterol decreased by approximately 77% and 66% following LDL-apheresis an

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Nutritional Science and Vitaminology

ISSN

0301-4800

e-ISSN

—

Svazek periodika

61

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

JP - Japonsko

Počet stran výsledku

8

Strana od-do

105-112

Kód UT WoS článku

000355020000001

EID výsledku v databázi Scopus

2-s2.0-84930703098