The effect of Myrica rubra essential oil and its components alpha-humulene and trans-nerolidol on adhesion and apoptosis of colorectal cancer cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10312977" target="_blank" >RIV/00216208:11150/15:10312977 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.smartscitech.com/index.php/CCM/article/view/1058/pdf_128" target="_blank" >http://www.smartscitech.com/index.php/CCM/article/view/1058/pdf_128</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14800/ccm.1058" target="_blank" >10.14800/ccm.1058</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The effect of Myrica rubra essential oil and its components alpha-humulene and trans-nerolidol on adhesion and apoptosis of colorectal cancer cells

Popis výsledku v původním jazyce

Essential oil from leaves of Myrica rubra (MEO), a subtropical Asian fruit tree with traditional use in folk medicines, had significant antiproliferative effect in several intestinal cancer cell lines. In present study, we tested the influence of MEO andits most effective compounds alpha-humulene and trans-nerolidol on the cell adhesion, expression of adhesion molecules (ICAM-1; E-cadherin; beta-catenin) and apoptotic molecules (NF-kappaB, caspases) in colorectal cancer cell line HT29. All parameters were followed up and compared in presence or absence of pro-inflammatory agent TNFalpha. The results showed that MEO was able to decrease adhesion of colon cancer HT29 cells to collagen. Furthermore MEO, alpha-humulene and trans-nerolidol significantly suppressed adhesion of TNFalpha-induced cells probably due to down-regulation of ICAM-1. Moreover, MEO and alpha-humulene could diminish tumor invasion and metastasis via up-regulation of E-cadherin. In presence of TNFalpha, MEO and trans-n

Název v anglickém jazyce

The effect of Myrica rubra essential oil and its components alpha-humulene and trans-nerolidol on adhesion and apoptosis of colorectal cancer cells

Popis výsledku anglicky

Essential oil from leaves of Myrica rubra (MEO), a subtropical Asian fruit tree with traditional use in folk medicines, had significant antiproliferative effect in several intestinal cancer cell lines. In present study, we tested the influence of MEO andits most effective compounds alpha-humulene and trans-nerolidol on the cell adhesion, expression of adhesion molecules (ICAM-1; E-cadherin; beta-catenin) and apoptotic molecules (NF-kappaB, caspases) in colorectal cancer cell line HT29. All parameters were followed up and compared in presence or absence of pro-inflammatory agent TNFalpha. The results showed that MEO was able to decrease adhesion of colon cancer HT29 cells to collagen. Furthermore MEO, alpha-humulene and trans-nerolidol significantly suppressed adhesion of TNFalpha-induced cells probably due to down-regulation of ICAM-1. Moreover, MEO and alpha-humulene could diminish tumor invasion and metastasis via up-regulation of E-cadherin. In presence of TNFalpha, MEO and trans-n

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cancer Cell &amp; Microenvironment

ISSN

2331-0928

e-ISSN

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Svazek periodika

2

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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