The effect of different doses of atropine on gastric myoelectrical activity in fasting experimental pigs

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10314760" target="_blank" >RIV/00216208:11150/15:10314760 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G44__/15:43875431 RIV/00179906:_____/15:10314760

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jab.2015.04.004" target="_blank" >http://dx.doi.org/10.1016/j.jab.2015.04.004</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jab.2015.04.004" target="_blank" >10.1016/j.jab.2015.04.004</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The effect of different doses of atropine on gastric myoelectrical activity in fasting experimental pigs

Popis výsledku v původním jazyce

Electrogastrography (EGG) is a non-invasive method for the assessment of gastric myoelectrical activity. Porcine EGG is comparable with human one. There are no data on the impact of moderate to high doses of atropine on EGG, neither in humans nor experimental pigs. The purpose of this study was to evaluate the effect of different doses of atropine on EGG in experimental pigs. Six fasting pigs entered the study three times in a random order. The baseline EGG recording lasted 20 min, followed by a 105-minEGG trial recording. Intramuscular atropine 1.5 mg (part 1), 3.0 mg (part 2) and 4.5 mg (part 3) was administrated after the baseline EGG. Atropine doses of 1.5 and 3.0 mg revealed a similar pattern in the EGG power course. After an initial increase (atthe first 15-min interval), the areas of amplitudes decreased back to values comparable with basal levels and subsequently increased significantly again to the maximum at 105 min. The EGG power was quite different after the administratio

Název v anglickém jazyce

The effect of different doses of atropine on gastric myoelectrical activity in fasting experimental pigs

Popis výsledku anglicky

Electrogastrography (EGG) is a non-invasive method for the assessment of gastric myoelectrical activity. Porcine EGG is comparable with human one. There are no data on the impact of moderate to high doses of atropine on EGG, neither in humans nor experimental pigs. The purpose of this study was to evaluate the effect of different doses of atropine on EGG in experimental pigs. Six fasting pigs entered the study three times in a random order. The baseline EGG recording lasted 20 min, followed by a 105-minEGG trial recording. Intramuscular atropine 1.5 mg (part 1), 3.0 mg (part 2) and 4.5 mg (part 3) was administrated after the baseline EGG. Atropine doses of 1.5 and 3.0 mg revealed a similar pattern in the EGG power course. After an initial increase (atthe first 15-min interval), the areas of amplitudes decreased back to values comparable with basal levels and subsequently increased significantly again to the maximum at 105 min. The EGG power was quite different after the administratio

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

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Projekt

<a href="/cs/project/NT14270" target="_blank" >NT14270: Farmakokinetika a gastrointestinální motorické účinky nových acetylcholinesterasových modulátorů u experimentálních prasat</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Applied Biomedicine

ISSN

1214-021X

e-ISSN

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Svazek periodika

13

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

273-277

Kód UT WoS článku

000362983300003

EID výsledku v databázi Scopus

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