Inhibitory CD200R and proapoptotic CD95/CD95L molecules on innate immunity cells are modulated by cardiac surgery

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10315649" target="_blank" >RIV/00216208:11150/15:10315649 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/15:10315649

Výsledek na webu

<a href="http://dx.doi.org/10.1177/0267659114558286" target="_blank" >http://dx.doi.org/10.1177/0267659114558286</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/0267659114558286" target="_blank" >10.1177/0267659114558286</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Inhibitory CD200R and proapoptotic CD95/CD95L molecules on innate immunity cells are modulated by cardiac surgery

Popis výsledku v původním jazyce

Cardiac surgery directly initiates a systemic inflammatory response with the activation of both cellular and humoral parts of the immune system. Exaggerated immune system activation is associated with a risk of life-threatening multi-organ dysfunction and increased morbidity and mortality in the postoperative period. The immune system response is regulated and terminated by inhibitory mechanisms, including the regulatory membrane molecules, such as CD200R, CD95, CD95L and soluble sCD200R. We measured the expression of CD95, CD95L, CD200R and sCD200R molecules in granulocyte and monocyte populations in blood samples of 30 patients who underwent coronary artery bypass grafting using cardiopulmonary bypass. Samples collected before surgery, after surgeryand in the postoperative period were analyzed by flow cytometry and ELISA. We found a significant increase in the percentage of granulocytes featuring the anti-inflammatory molecule CD200R after surgery. We presume that these cells were l

Název v anglickém jazyce

Inhibitory CD200R and proapoptotic CD95/CD95L molecules on innate immunity cells are modulated by cardiac surgery

Popis výsledku anglicky

Cardiac surgery directly initiates a systemic inflammatory response with the activation of both cellular and humoral parts of the immune system. Exaggerated immune system activation is associated with a risk of life-threatening multi-organ dysfunction and increased morbidity and mortality in the postoperative period. The immune system response is regulated and terminated by inhibitory mechanisms, including the regulatory membrane molecules, such as CD200R, CD95, CD95L and soluble sCD200R. We measured the expression of CD95, CD95L, CD200R and sCD200R molecules in granulocyte and monocyte populations in blood samples of 30 patients who underwent coronary artery bypass grafting using cardiopulmonary bypass. Samples collected before surgery, after surgeryand in the postoperative period were analyzed by flow cytometry and ELISA. We found a significant increase in the percentage of granulocytes featuring the anti-inflammatory molecule CD200R after surgery. We presume that these cells were l

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Perfusion

ISSN

0267-6591

e-ISSN

—

Svazek periodika

30

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

543-555

Kód UT WoS článku

000361978000010

EID výsledku v databázi Scopus

2-s2.0-84942565998