Effects of Arginine Supplementation on Amino Acid Profiles in Blood and Tissues in Fed and Overnight Fasted Rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F16%3A10323180" target="_blank" >RIV/00216208:11150/16:10323180 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.3390/nu8040206" target="_blank" >http://dx.doi.org/10.3390/nu8040206</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/nu8040206" target="_blank" >10.3390/nu8040206</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effects of Arginine Supplementation on Amino Acid Profiles in Blood and Tissues in Fed and Overnight Fasted Rats

Popis výsledku v původním jazyce

We evaluated the effect of chronic intake of arginine on amino acid concentrations in blood plasma, liver, kidneys, and soleus and extensor digitorum longus muscles. Rats were fed a standard diet or a high-arginine diet (HAD) for two months. Half of the animals in each group were sacrificed in the fed state, and the other half after overnight fast. HAD increased blood plasma concentrations of urea, creatinine, arginine, and ornithine and decreased most of other amino acids. Arginine and ornithine increased also in muscles and kidneys. In most of examined tissues decreased methionine, phenylalanine, threonine, asparagine, glycine, serine, and taurine. An increase of lysine was observed in both muscle types. After overnight fast the most of the effects of HAD disappeared. It is concluded that enhanced dietary arginine intake alters distribution of almost all amino acids, and that to get a clear picture about the effects of various nutritional interventions some biochemical measurements should be performed both in postprandial and postabsorptive states.

Název v anglickém jazyce

Effects of Arginine Supplementation on Amino Acid Profiles in Blood and Tissues in Fed and Overnight Fasted Rats

Popis výsledku anglicky

We evaluated the effect of chronic intake of arginine on amino acid concentrations in blood plasma, liver, kidneys, and soleus and extensor digitorum longus muscles. Rats were fed a standard diet or a high-arginine diet (HAD) for two months. Half of the animals in each group were sacrificed in the fed state, and the other half after overnight fast. HAD increased blood plasma concentrations of urea, creatinine, arginine, and ornithine and decreased most of other amino acids. Arginine and ornithine increased also in muscles and kidneys. In most of examined tissues decreased methionine, phenylalanine, threonine, asparagine, glycine, serine, and taurine. An increase of lysine was observed in both muscle types. After overnight fast the most of the effects of HAD disappeared. It is concluded that enhanced dietary arginine intake alters distribution of almost all amino acids, and that to get a clear picture about the effects of various nutritional interventions some biochemical measurements should be performed both in postprandial and postabsorptive states.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nutrients

ISSN

2072-6643

e-ISSN

—

Svazek periodika

8

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

11

Strana od-do

—

Kód UT WoS článku

000374590200029

EID výsledku v databázi Scopus

2-s2.0-84962860710