Pattern- and motion-related visual evoked potentials in HIV-infected adults

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F17%3A10332329" target="_blank" >RIV/00216208:11150/17:10332329 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/17:10332329

Výsledek na webu

<a href="http://link.springer.com/article/10.1007/s10633-016-9570-x" target="_blank" >http://link.springer.com/article/10.1007/s10633-016-9570-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10633-016-9570-x" target="_blank" >10.1007/s10633-016-9570-x</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Pattern- and motion-related visual evoked potentials in HIV-infected adults

Popis výsledku v původním jazyce

Purpose: The goal of the current study was to explore visual function in virally suppressed HIV patients undergoing combined antiretroviral therapy (cART) by using pattern-reversal and motion-onset visual evoked potentials (VEPs). Methods: The pattern-reversal and motion-onset VEPs were recorded in 20 adult HIV+ patients with a mean age of 38 years and CD4 cell counts GREATER-THAN OR EQUAL TO230 x 106 cells/L of blood. Results Nine out of 20 patients displayed VEP abnormalities. Pattern-reversal VEPs pathology was observed in 20% of subjects and 45% HIV patients had impaired motion-onset VEPs. Five out of 16 neurologically asymptomatic HIV patients had prolonged motion-onset VEP latencies in both eyes. Four neurologically symptomatic patients displayed simultaneously abnormal motion-onset and pattern-reversal VEP latencies: monocular involvement was observed in two patients with Lyme and Cytomegalovirus unilateral Optic Neuritis. Binocular involvement was noted in two patients with cognitive deficits. Correlation analysis between disease duration, CD4 cell count, HIV copies in plasma, MoCA and electrophysiological parameters did not show any significant relationships. Conclusions: The functional changes of the visual system in neurologically asymptomatic virally suppressed HIV patients displayed higher motion-onset VEP sensitivity than in standard pattern-reversal VEP examinations. This promising marker, however, has no significant association with clinical conditions. Further exploration is warranted.

Název v anglickém jazyce

Pattern- and motion-related visual evoked potentials in HIV-infected adults

Popis výsledku anglicky

Purpose: The goal of the current study was to explore visual function in virally suppressed HIV patients undergoing combined antiretroviral therapy (cART) by using pattern-reversal and motion-onset visual evoked potentials (VEPs). Methods: The pattern-reversal and motion-onset VEPs were recorded in 20 adult HIV+ patients with a mean age of 38 years and CD4 cell counts GREATER-THAN OR EQUAL TO230 x 106 cells/L of blood. Results Nine out of 20 patients displayed VEP abnormalities. Pattern-reversal VEPs pathology was observed in 20% of subjects and 45% HIV patients had impaired motion-onset VEPs. Five out of 16 neurologically asymptomatic HIV patients had prolonged motion-onset VEP latencies in both eyes. Four neurologically symptomatic patients displayed simultaneously abnormal motion-onset and pattern-reversal VEP latencies: monocular involvement was observed in two patients with Lyme and Cytomegalovirus unilateral Optic Neuritis. Binocular involvement was noted in two patients with cognitive deficits. Correlation analysis between disease duration, CD4 cell count, HIV copies in plasma, MoCA and electrophysiological parameters did not show any significant relationships. Conclusions: The functional changes of the visual system in neurologically asymptomatic virally suppressed HIV patients displayed higher motion-onset VEP sensitivity than in standard pattern-reversal VEP examinations. This promising marker, however, has no significant association with clinical conditions. Further exploration is warranted.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Documenta Ophthalmologica

ISSN

0012-4486

e-ISSN

—

Svazek periodika

134

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

45-55

Kód UT WoS článku

000397199000005

EID výsledku v databázi Scopus

2-s2.0-85009170718