Anthropometric features are not predictive of 72-hour fast duration in insulinomas

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F17%3A10365943" target="_blank" >RIV/00216208:11150/17:10365943 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/17:10365943

Výsledek na webu

<a href="http://dx.doi.org/10.4158/EP171872.OR" target="_blank" >http://dx.doi.org/10.4158/EP171872.OR</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4158/EP171872.OR" target="_blank" >10.4158/EP171872.OR</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Anthropometric features are not predictive of 72-hour fast duration in insulinomas

Popis výsledku v původním jazyce

Objective: The 72-hour fast is used to document Whipple&apos;s triad and understand the mechanism of hypoglycemia. Although hypoglycemia develops within 24 hours in the majority of fasts, identifying possible determinants of fast duration may help to predict the need for admission. Therefore, we determined the relation between anthropometric features on fast duration and assessed end of fast parameters on maximal tumor size, extent of disease, or tumor recurrence. Methods: A retrospective analysis of patients with insulinoma in the past 25 years who underwent a 72-hour fast was conducted. Electronic medical records were reviewed to obtain anthropometric patient data and tumor characteristics. Results: A total of 233 patients underwent the 72-hour fast. The mean age at diagnosis was 50 +/- 16 years, with a body mass index (BMI) of 29 +/- 7 kg/m(2), and 66% (153 of 233) were female. Duration of fast was not associated with gender (P = .2), age (P = .3), or BMI (P = .7). A shorter fast duration was inversely related to end of fast C-peptide (P = .0075) but not insulin (P = .13) or proinsulin (P = .28) concentration. End of fast C-peptide was associated with increased tumor size (P = .036) and multiplicity (P = .01). Proinsulin was associated with increased tumor size (P&lt;.01) and malignancy (P = .018). Conclusion: Duration of fast was not significantly related age, gender, weight, or BMI, although end-of-fast C-peptide and proinsulin may provide some information regarding tumor characteristics. Consequently, the duration of fast cannot be predicted a priori and should be allowed to run for the planned length unless hypoglycemia develops.

Název v anglickém jazyce

Anthropometric features are not predictive of 72-hour fast duration in insulinomas

Popis výsledku anglicky

Objective: The 72-hour fast is used to document Whipple&apos;s triad and understand the mechanism of hypoglycemia. Although hypoglycemia develops within 24 hours in the majority of fasts, identifying possible determinants of fast duration may help to predict the need for admission. Therefore, we determined the relation between anthropometric features on fast duration and assessed end of fast parameters on maximal tumor size, extent of disease, or tumor recurrence. Methods: A retrospective analysis of patients with insulinoma in the past 25 years who underwent a 72-hour fast was conducted. Electronic medical records were reviewed to obtain anthropometric patient data and tumor characteristics. Results: A total of 233 patients underwent the 72-hour fast. The mean age at diagnosis was 50 +/- 16 years, with a body mass index (BMI) of 29 +/- 7 kg/m(2), and 66% (153 of 233) were female. Duration of fast was not associated with gender (P = .2), age (P = .3), or BMI (P = .7). A shorter fast duration was inversely related to end of fast C-peptide (P = .0075) but not insulin (P = .13) or proinsulin (P = .28) concentration. End of fast C-peptide was associated with increased tumor size (P = .036) and multiplicity (P = .01). Proinsulin was associated with increased tumor size (P&lt;.01) and malignancy (P = .018). Conclusion: Duration of fast was not significantly related age, gender, weight, or BMI, although end-of-fast C-peptide and proinsulin may provide some information regarding tumor characteristics. Consequently, the duration of fast cannot be predicted a priori and should be allowed to run for the planned length unless hypoglycemia develops.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Endocrine Practice

ISSN

1530-891X

e-ISSN

—

Svazek periodika

23

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

923-928

Kód UT WoS článku

000411114800004

EID výsledku v databázi Scopus

2-s2.0-85029811626