Mast cells in calcific aortic stenosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F18%3A10368523" target="_blank" >RIV/00216208:11150/18:10368523 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/18:10368523

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.prp.2017.07.016" target="_blank" >http://dx.doi.org/10.1016/j.prp.2017.07.016</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.prp.2017.07.016" target="_blank" >10.1016/j.prp.2017.07.016</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mast cells in calcific aortic stenosis

Popis výsledku v původním jazyce

In developed countries, calcific aortic stenosis(CAS) has become the most common acquired valvular disease and reason for aortic valve replacement. It is considered a form of atherosclerosis, like the latter, of inflammatory origin, with presence in the calcified aortic valves of blood vessels, lymphatics, lymphocytes, plasma cells, histiocytes, and sometimes also of metaplastic bone tissue. This study is aimed at examining the presence of CD117 - positive mast cells in CAS. In 56 examined calcified aortic valves excised by cardiac surgery, mast cells were constantly present as a part of the polymorphous cellular infiltrate; in individual cases, their numbers were 1-90 (median 24). The numbers were significantly higher in the congenitally malformed/biscupid valves (median 40) than in the tricuspid ones (median 20). In valves with presence of metaplastic bone, mast cells were significantly more numerous (median 42) than in those without metaplasia (median 20). In 12 normal aortic valves obtained at autopsies, the numbers of mast cells were 4-21 (median 11). Discussed is a possible role of mast cells in pathogenesis of CAS.

Název v anglickém jazyce

Mast cells in calcific aortic stenosis

Popis výsledku anglicky

In developed countries, calcific aortic stenosis(CAS) has become the most common acquired valvular disease and reason for aortic valve replacement. It is considered a form of atherosclerosis, like the latter, of inflammatory origin, with presence in the calcified aortic valves of blood vessels, lymphatics, lymphocytes, plasma cells, histiocytes, and sometimes also of metaplastic bone tissue. This study is aimed at examining the presence of CD117 - positive mast cells in CAS. In 56 examined calcified aortic valves excised by cardiac surgery, mast cells were constantly present as a part of the polymorphous cellular infiltrate; in individual cases, their numbers were 1-90 (median 24). The numbers were significantly higher in the congenitally malformed/biscupid valves (median 40) than in the tricuspid ones (median 20). In valves with presence of metaplastic bone, mast cells were significantly more numerous (median 42) than in those without metaplasia (median 20). In 12 normal aortic valves obtained at autopsies, the numbers of mast cells were 4-21 (median 11). Discussed is a possible role of mast cells in pathogenesis of CAS.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

<a href="/cs/project/LM2015089" target="_blank" >LM2015089: Banka klinických vzorků</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pathology: Research and Practice

ISSN

0344-0338

e-ISSN

—

Svazek periodika

214

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

6

Strana od-do

163-168

Kód UT WoS článku

000429086000024

EID výsledku v databázi Scopus

2-s2.0-85034851927