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The effect of levetiracetam on rat bone mineral density, bone structure and biochemical markers of bone metabolism

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F18%3A10372247" target="_blank" >RIV/00216208:11150/18:10372247 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00216208:11160/18:10372247 RIV/00179906:_____/18:10372247

  • Výsledek na webu

    <a href="http://www.sciencedirect.com/science/article/pii/S0014299918300888" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0014299918300888</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.ejphar.2018.02.010" target="_blank" >10.1016/j.ejphar.2018.02.010</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    The effect of levetiracetam on rat bone mineral density, bone structure and biochemical markers of bone metabolism

  • Popis výsledku v původním jazyce

    Some data suggest that exposure to levetiracetam (LEV) might be associated with a risk for bone health in the model of orchidectomized rats. The aim of this study was to investigate if there is any significant risk of LEV for bone health in the model of gonadally intact animals. Wistar rats were divided into a control group and a test group, 8 rats in each group. The control rats received standard laboratory diet (SLD) while rats in the test group were fed SLD enriched with LEV for 12 weeks. Dual energy X-ray absorptiometry was used to measure BMD of the whole body, femur and lumbar vertebrae. The concentrations of bone markers were examined in bone homogenate. Both femurs and tibiae were used for biomechanical testing. We found in the LEV group significantly decreased absolute and relative values of adipose tissue, higher whole-body BMD, higher right tibia cortical thickness, and a significantly increased concentration of Bone Alkaline Phosphatase (BALP) and cross-linked C-telopeptide of type I collagen (CTX-I) compared with the control group. The results suggest that the long-term administration of LEV in the model of gonadally intact rats does not have a negative effect on bone. Significant increase in BMD and cortical thickness of the right tibia may indicate even a positive influence on the properties of bone. Further studies will be necessary in animals and humans to confirm these findings.

  • Název v anglickém jazyce

    The effect of levetiracetam on rat bone mineral density, bone structure and biochemical markers of bone metabolism

  • Popis výsledku anglicky

    Some data suggest that exposure to levetiracetam (LEV) might be associated with a risk for bone health in the model of orchidectomized rats. The aim of this study was to investigate if there is any significant risk of LEV for bone health in the model of gonadally intact animals. Wistar rats were divided into a control group and a test group, 8 rats in each group. The control rats received standard laboratory diet (SLD) while rats in the test group were fed SLD enriched with LEV for 12 weeks. Dual energy X-ray absorptiometry was used to measure BMD of the whole body, femur and lumbar vertebrae. The concentrations of bone markers were examined in bone homogenate. Both femurs and tibiae were used for biomechanical testing. We found in the LEV group significantly decreased absolute and relative values of adipose tissue, higher whole-body BMD, higher right tibia cortical thickness, and a significantly increased concentration of Bone Alkaline Phosphatase (BALP) and cross-linked C-telopeptide of type I collagen (CTX-I) compared with the control group. The results suggest that the long-term administration of LEV in the model of gonadally intact rats does not have a negative effect on bone. Significant increase in BMD and cortical thickness of the right tibia may indicate even a positive influence on the properties of bone. Further studies will be necessary in animals and humans to confirm these findings.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    10608 - Biochemistry and molecular biology

Návaznosti výsledku

  • Projekt

  • Návaznosti

    S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2018

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    European Journal of Pharmacology

  • ISSN

    0014-2999

  • e-ISSN

  • Svazek periodika

    824

  • Číslo periodika v rámci svazku

    April

  • Stát vydavatele periodika

    NL - Nizozemsko

  • Počet stran výsledku

    5

  • Strana od-do

    115-119

  • Kód UT WoS článku

    000427523100015

  • EID výsledku v databázi Scopus

    2-s2.0-85042057657