Effect of Ivabradine on a Hypertensive Heart and the Renin-Angiotensin-Aldosterone System in L-NAME-Induced Hypertension

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F18%3A10381381" target="_blank" >RIV/00216208:11150/18:10381381 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.mdpi.com/1422-0067/19/10/3017" target="_blank" >https://www.mdpi.com/1422-0067/19/10/3017</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms19103017" target="_blank" >10.3390/ijms19103017</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of Ivabradine on a Hypertensive Heart and the Renin-Angiotensin-Aldosterone System in L-NAME-Induced Hypertension

Popis výsledku v původním jazyce

This study investigated whether ivabradine is able to protect a hypertensive heart in the model of L-NAME-induced hypertension and to interfere with the RAAS. L-NAME administration increased systolic blood pressure and left ventricular weight, enhanced hydroxyproline concentration in the LV, and deteriorated the systolic and diastolic LV function. Ivabradine reduced HR and SBP, and improved the LV function. The serum concentrations of angiotensin Ang 1-8 (Ang II), Ang 1-5, Ang 1-7, Ang 1-10, Ang 2-8, and Ang 3-8 were decreased in the L-NAME group and ivabradine did not modify them. The serum concentration of aldosterone was enhanced by L-NAME and ivabradine reduced these changes. We conclude that the protective effect of ivabradine might have been associated with the reduction of the aldosterone level.

Název v anglickém jazyce

Effect of Ivabradine on a Hypertensive Heart and the Renin-Angiotensin-Aldosterone System in L-NAME-Induced Hypertension

Popis výsledku anglicky

This study investigated whether ivabradine is able to protect a hypertensive heart in the model of L-NAME-induced hypertension and to interfere with the RAAS. L-NAME administration increased systolic blood pressure and left ventricular weight, enhanced hydroxyproline concentration in the LV, and deteriorated the systolic and diastolic LV function. Ivabradine reduced HR and SBP, and improved the LV function. The serum concentrations of angiotensin Ang 1-8 (Ang II), Ang 1-5, Ang 1-7, Ang 1-10, Ang 2-8, and Ang 3-8 were decreased in the L-NAME group and ivabradine did not modify them. The serum concentration of aldosterone was enhanced by L-NAME and ivabradine reduced these changes. We conclude that the protective effect of ivabradine might have been associated with the reduction of the aldosterone level.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30105 - Physiology (including cytology)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Molecular Sciences

ISSN

1422-0067

e-ISSN

—

Svazek periodika

19

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

15

Strana od-do

—

Kód UT WoS článku

000448951000172

EID výsledku v databázi Scopus

2-s2.0-85054440428