Respiratory parameters predict poor outcome in COPD patients, category GOLD 2017 B

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F18%3A10381465" target="_blank" >RIV/00216208:11150/18:10381465 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/18:00103237 RIV/00179906:_____/18:10381465 RIV/00064211:_____/18:W0000139 RIV/00064190:_____/18:N0000046

Výsledek na webu

<a href="https://doi.org/10.2147/COPD.S147262" target="_blank" >https://doi.org/10.2147/COPD.S147262</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2147/COPD.S147262" target="_blank" >10.2147/COPD.S147262</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Respiratory parameters predict poor outcome in COPD patients, category GOLD 2017 B

Popis výsledku v původním jazyce

Background: Respiratory parameters are important predictors of prognosis in the COPD population. Global Initiative for Obstructive Lung Disease (GOLD) 2017 Update resulted in a vertical shift of patients across COPD categories, with category B being the most populous and clinically heterogeneous. The aim of our study was to investigate whether respiratory parameters might be associated with increased all-cause mortality within GOLD category B patients. Methods: The data were extracted from the Czech Multicentre Research Database, a prospective, noninterventional multicenter study of COPD patients. Kaplan-Meier survival analyses were performed at different levels of respiratory parameters (partial pressure of oxygen in arterial blood [PaO2], partial pressure of arterial carbon dioxide [PaCO2] and greatest decrease of basal peripheral capillary oxygen saturation during 6-minute walking test [6-MWT]). Univariate analyses using the Cox proportional hazard model and multivariate analyses were used to identify risk factors for mortality in hypoxemic and hypercapnic individuals with COPD. Results: All-cause mortality in the cohort at 3 years of prospective follow-up reached 18.4%. Chronic hypoxemia (PaO2 &lt; 7.3 kPa), hypercapnia (PaCO2 &gt; 7.0 kPa) and oxygen desaturation during the 6-MWT were predictors of long-term mortality in COPD patients with forced expiratory volume in 1 second &lt;= 60% for the overall cohort and for GOLD B category patients. Univariate analyses confirmed the association among decreased oxemia (&lt; 7.3 kPa), increased capnemia (&gt; 7.0 kPa), oxygen desaturation during 6-MWT and mortality in the studied groups of COPD subjects. Multivariate analysis identified PaO2 &lt; 7.3 kPa as a strong independent risk factor for mortality. Conclusion: Survival analyses showed significantly increased all-cause mortality in hypoxemic and hypercapnic GOLD B subjects. More important, PaO2 &lt; 7.3 kPa was the strongest risk factor, especially in category B patients. In contrast, the majority of the tested respiratory parameters did not show a difference in mortality in the GOLD category D cohort.

Název v anglickém jazyce

Respiratory parameters predict poor outcome in COPD patients, category GOLD 2017 B

Popis výsledku anglicky

Background: Respiratory parameters are important predictors of prognosis in the COPD population. Global Initiative for Obstructive Lung Disease (GOLD) 2017 Update resulted in a vertical shift of patients across COPD categories, with category B being the most populous and clinically heterogeneous. The aim of our study was to investigate whether respiratory parameters might be associated with increased all-cause mortality within GOLD category B patients. Methods: The data were extracted from the Czech Multicentre Research Database, a prospective, noninterventional multicenter study of COPD patients. Kaplan-Meier survival analyses were performed at different levels of respiratory parameters (partial pressure of oxygen in arterial blood [PaO2], partial pressure of arterial carbon dioxide [PaCO2] and greatest decrease of basal peripheral capillary oxygen saturation during 6-minute walking test [6-MWT]). Univariate analyses using the Cox proportional hazard model and multivariate analyses were used to identify risk factors for mortality in hypoxemic and hypercapnic individuals with COPD. Results: All-cause mortality in the cohort at 3 years of prospective follow-up reached 18.4%. Chronic hypoxemia (PaO2 &lt; 7.3 kPa), hypercapnia (PaCO2 &gt; 7.0 kPa) and oxygen desaturation during the 6-MWT were predictors of long-term mortality in COPD patients with forced expiratory volume in 1 second &lt;= 60% for the overall cohort and for GOLD B category patients. Univariate analyses confirmed the association among decreased oxemia (&lt; 7.3 kPa), increased capnemia (&gt; 7.0 kPa), oxygen desaturation during 6-MWT and mortality in the studied groups of COPD subjects. Multivariate analysis identified PaO2 &lt; 7.3 kPa as a strong independent risk factor for mortality. Conclusion: Survival analyses showed significantly increased all-cause mortality in hypoxemic and hypercapnic GOLD B subjects. More important, PaO2 &lt; 7.3 kPa was the strongest risk factor, especially in category B patients. In contrast, the majority of the tested respiratory parameters did not show a difference in mortality in the GOLD category D cohort.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30203 - Respiratory systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Chronic Obstructive Pulmonary Disease [online]

ISSN

1178-2005

e-ISSN

—

Svazek periodika

13

Číslo periodika v rámci svazku

March

Stát vydavatele periodika

NZ - Nový Zéland

Počet stran výsledku

16

Strana od-do

1037-1052

Kód UT WoS článku

000428799800002

EID výsledku v databázi Scopus

2-s2.0-85044778267