The ETV6-RET Gene Fusion Is Found in ETV6-rearranged Low-grade Sinonasal Adenocarcinoma Without NTRK3 Involvement
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F18%3A10382558" target="_blank" >RIV/00216208:11150/18:10382558 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00179906:_____/18:10382558
Výsledek na webu
<a href="https://doi.org/10.1097/PAS.0000000000001069" target="_blank" >https://doi.org/10.1097/PAS.0000000000001069</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/PAS.0000000000001069" target="_blank" >10.1097/PAS.0000000000001069</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The ETV6-RET Gene Fusion Is Found in ETV6-rearranged Low-grade Sinonasal Adenocarcinoma Without NTRK3 Involvement
Popis výsledku v původním jazyce
Recently, a novel translocation-associated carcinoma restricted to the sinonasal tract, the ETV6-rearranged low-grade sinonasal adenocarcinoma (SNAC) was reported. This entity is morphologically and immunohistochemically different from secretory carcinoma (SC) of the salivary glands, but harbours an identical fusion between exon 5 of ETV6 and exon 15 of NTRK3. Herein, we report an unique case of ETV6-RET low-grade SNAC occurring in 32-year-old female. The tumor originated in the maxillary sinus and extended into the middle meatus. Microscopically, the tumor was tubular with focal cystic change, and consisted of cuboidal to cylindrical cells with bright, eosinophilic cytoplasm. Immunohistochemically, the tumor cells were diffusely positive for CK7, GCDFP-15, SOX10, and vimentin, and negative for CK20, GATA3, and mammaglobin. As seems to be characteristic for ETV6-rearranged low-grade SNAC, DOG-1 was positive, and S-100 showed patchy expression. Fluorescence in situ hybridization demonstrated split signals for the ETV6 as well as RET probes, but intact NTRK3 signals. The next-generation sequencing panel confirmed an in-frame fusion between exon 6 of ETV6 and exon 12 of RET with 80 fusion-spanning reads. Our identification of the ETV6-RET gene fusion in ETV6-rearranged low-grade SNAC is intriguing, as it further strengthens the genetic ties between this tumor entity and SC. The significance of separating the morphologically different, but genetically identical ETV6-rearranged low-grade SNAC and sinonasal SC, awaits reports of clinical outcomes in larger series of both tumor types.
Název v anglickém jazyce
The ETV6-RET Gene Fusion Is Found in ETV6-rearranged Low-grade Sinonasal Adenocarcinoma Without NTRK3 Involvement
Popis výsledku anglicky
Recently, a novel translocation-associated carcinoma restricted to the sinonasal tract, the ETV6-rearranged low-grade sinonasal adenocarcinoma (SNAC) was reported. This entity is morphologically and immunohistochemically different from secretory carcinoma (SC) of the salivary glands, but harbours an identical fusion between exon 5 of ETV6 and exon 15 of NTRK3. Herein, we report an unique case of ETV6-RET low-grade SNAC occurring in 32-year-old female. The tumor originated in the maxillary sinus and extended into the middle meatus. Microscopically, the tumor was tubular with focal cystic change, and consisted of cuboidal to cylindrical cells with bright, eosinophilic cytoplasm. Immunohistochemically, the tumor cells were diffusely positive for CK7, GCDFP-15, SOX10, and vimentin, and negative for CK20, GATA3, and mammaglobin. As seems to be characteristic for ETV6-rearranged low-grade SNAC, DOG-1 was positive, and S-100 showed patchy expression. Fluorescence in situ hybridization demonstrated split signals for the ETV6 as well as RET probes, but intact NTRK3 signals. The next-generation sequencing panel confirmed an in-frame fusion between exon 6 of ETV6 and exon 12 of RET with 80 fusion-spanning reads. Our identification of the ETV6-RET gene fusion in ETV6-rearranged low-grade SNAC is intriguing, as it further strengthens the genetic ties between this tumor entity and SC. The significance of separating the morphologically different, but genetically identical ETV6-rearranged low-grade SNAC and sinonasal SC, awaits reports of clinical outcomes in larger series of both tumor types.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30109 - Pathology
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
The American Journal of Surgical Pathology
ISSN
0147-5185
e-ISSN
—
Svazek periodika
42
Číslo periodika v rámci svazku
7
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
4
Strana od-do
985-988
Kód UT WoS článku
000435472600017
EID výsledku v databázi Scopus
2-s2.0-85048760936