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The ETV6-RET Gene Fusion Is Found in ETV6-rearranged Low-grade Sinonasal Adenocarcinoma Without NTRK3 Involvement

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F18%3A10382558" target="_blank" >RIV/00216208:11150/18:10382558 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00179906:_____/18:10382558

  • Výsledek na webu

    <a href="https://doi.org/10.1097/PAS.0000000000001069" target="_blank" >https://doi.org/10.1097/PAS.0000000000001069</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1097/PAS.0000000000001069" target="_blank" >10.1097/PAS.0000000000001069</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    The ETV6-RET Gene Fusion Is Found in ETV6-rearranged Low-grade Sinonasal Adenocarcinoma Without NTRK3 Involvement

  • Popis výsledku v původním jazyce

    Recently, a novel translocation-associated carcinoma restricted to the sinonasal tract, the ETV6-rearranged low-grade sinonasal adenocarcinoma (SNAC) was reported. This entity is morphologically and immunohistochemically different from secretory carcinoma (SC) of the salivary glands, but harbours an identical fusion between exon 5 of ETV6 and exon 15 of NTRK3. Herein, we report an unique case of ETV6-RET low-grade SNAC occurring in 32-year-old female. The tumor originated in the maxillary sinus and extended into the middle meatus. Microscopically, the tumor was tubular with focal cystic change, and consisted of cuboidal to cylindrical cells with bright, eosinophilic cytoplasm. Immunohistochemically, the tumor cells were diffusely positive for CK7, GCDFP-15, SOX10, and vimentin, and negative for CK20, GATA3, and mammaglobin. As seems to be characteristic for ETV6-rearranged low-grade SNAC, DOG-1 was positive, and S-100 showed patchy expression. Fluorescence in situ hybridization demonstrated split signals for the ETV6 as well as RET probes, but intact NTRK3 signals. The next-generation sequencing panel confirmed an in-frame fusion between exon 6 of ETV6 and exon 12 of RET with 80 fusion-spanning reads. Our identification of the ETV6-RET gene fusion in ETV6-rearranged low-grade SNAC is intriguing, as it further strengthens the genetic ties between this tumor entity and SC. The significance of separating the morphologically different, but genetically identical ETV6-rearranged low-grade SNAC and sinonasal SC, awaits reports of clinical outcomes in larger series of both tumor types.

  • Název v anglickém jazyce

    The ETV6-RET Gene Fusion Is Found in ETV6-rearranged Low-grade Sinonasal Adenocarcinoma Without NTRK3 Involvement

  • Popis výsledku anglicky

    Recently, a novel translocation-associated carcinoma restricted to the sinonasal tract, the ETV6-rearranged low-grade sinonasal adenocarcinoma (SNAC) was reported. This entity is morphologically and immunohistochemically different from secretory carcinoma (SC) of the salivary glands, but harbours an identical fusion between exon 5 of ETV6 and exon 15 of NTRK3. Herein, we report an unique case of ETV6-RET low-grade SNAC occurring in 32-year-old female. The tumor originated in the maxillary sinus and extended into the middle meatus. Microscopically, the tumor was tubular with focal cystic change, and consisted of cuboidal to cylindrical cells with bright, eosinophilic cytoplasm. Immunohistochemically, the tumor cells were diffusely positive for CK7, GCDFP-15, SOX10, and vimentin, and negative for CK20, GATA3, and mammaglobin. As seems to be characteristic for ETV6-rearranged low-grade SNAC, DOG-1 was positive, and S-100 showed patchy expression. Fluorescence in situ hybridization demonstrated split signals for the ETV6 as well as RET probes, but intact NTRK3 signals. The next-generation sequencing panel confirmed an in-frame fusion between exon 6 of ETV6 and exon 12 of RET with 80 fusion-spanning reads. Our identification of the ETV6-RET gene fusion in ETV6-rearranged low-grade SNAC is intriguing, as it further strengthens the genetic ties between this tumor entity and SC. The significance of separating the morphologically different, but genetically identical ETV6-rearranged low-grade SNAC and sinonasal SC, awaits reports of clinical outcomes in larger series of both tumor types.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30109 - Pathology

Návaznosti výsledku

  • Projekt

  • Návaznosti

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2018

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    The American Journal of Surgical Pathology

  • ISSN

    0147-5185

  • e-ISSN

  • Svazek periodika

    42

  • Číslo periodika v rámci svazku

    7

  • Stát vydavatele periodika

    US - Spojené státy americké

  • Počet stran výsledku

    4

  • Strana od-do

    985-988

  • Kód UT WoS článku

    000435472600017

  • EID výsledku v databázi Scopus

    2-s2.0-85048760936