Molecular and Ultrastructural Features of Diffuse Intrapulmonary Malignant Mesothelioma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F19%3A10496872" target="_blank" >RIV/00216208:11150/19:10496872 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=lW3BHUEDRo" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=lW3BHUEDRo</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/PAS.0000000000001143" target="_blank" >10.1097/PAS.0000000000001143</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Molecular and Ultrastructural Features of Diffuse Intrapulmonary Malignant Mesothelioma

Popis výsledku v původním jazyce

Diffuse malignant mesothelioma of the pleura typically presents with a pleural effusion and diffuse growth along pleural surfaces, producing a thickened pleura and pleural-based masses that can encase the lung in a thick rind. Diffuse involvement of the underlying pulmonary parenchyma without significant pleural disease is rare.Histopathologic confirmation of the diagnosis is usually not difficult, but when mesothelioma presents with a more unusual clinical or radiologic pattern of disease, its diagnosis can be more challenging. We recently reported 5 cases of diffuse intrapulmonary malignant mesothelioma (DIMM), a rare variant of mesothelioma with a distinctive pattern of predominantly intrapulmonary growth and minimal pleural involvement that clinically and radiologically simulates interstitial lung disease. To our knowledge, this remains the largest series to date of this peculiar phenomenon, but DIMM remains poorly understood. Understandably, some have questioned whether DIMM is truly mesotheliomatous, as its behavior and growth patterns are admittedly very unusual for a mesothelioma and its putative mesothelial nature has been based entirely on its morphologic and immunophenotypic features. To date, its molecular and ultrastructural characteristics have never been evaluated, prompting this communication.

Název v anglickém jazyce

Molecular and Ultrastructural Features of Diffuse Intrapulmonary Malignant Mesothelioma

Popis výsledku anglicky

Diffuse malignant mesothelioma of the pleura typically presents with a pleural effusion and diffuse growth along pleural surfaces, producing a thickened pleura and pleural-based masses that can encase the lung in a thick rind. Diffuse involvement of the underlying pulmonary parenchyma without significant pleural disease is rare.Histopathologic confirmation of the diagnosis is usually not difficult, but when mesothelioma presents with a more unusual clinical or radiologic pattern of disease, its diagnosis can be more challenging. We recently reported 5 cases of diffuse intrapulmonary malignant mesothelioma (DIMM), a rare variant of mesothelioma with a distinctive pattern of predominantly intrapulmonary growth and minimal pleural involvement that clinically and radiologically simulates interstitial lung disease. To our knowledge, this remains the largest series to date of this peculiar phenomenon, but DIMM remains poorly understood. Understandably, some have questioned whether DIMM is truly mesotheliomatous, as its behavior and growth patterns are admittedly very unusual for a mesothelioma and its putative mesothelial nature has been based entirely on its morphologic and immunophenotypic features. To date, its molecular and ultrastructural characteristics have never been evaluated, prompting this communication.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30109 - Pathology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American Journal of Surgical Pathology

ISSN

0147-5185

e-ISSN

1532-0979

Svazek periodika

43

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

147-150

Kód UT WoS článku

000454300400016

EID výsledku v databázi Scopus

2-s2.0-85052926828