Vitamin D status of very low birth weight infants at birth and the effects of generally recommended supplementation on their vitamin D levels at discharge

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F20%3A10399947" target="_blank" >RIV/00216208:11150/20:10399947 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/20:10399947

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=-nb7gShE9A" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=-nb7gShE9A</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/14767058.2019.1586873" target="_blank" >10.1080/14767058.2019.1586873</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Vitamin D status of very low birth weight infants at birth and the effects of generally recommended supplementation on their vitamin D levels at discharge

Popis výsledku v původním jazyce

To evaluate vitamin D status in mothers and their very low birth weight infants (VLBW) at birth (umbilical cord blood) and at discharge with currently recommended supplementation of vitamin D. Ninety-four infants with birth weight less than 1500 g completed the study. The total daily vitamin D intake was 800-1000 IU. We examined 25-hydroxyvitamin-D [25(OH)D] levels in maternal serum before labor, in cord blood, and in infants&apos;serum at discharge. Median (IQR) serum 25(OH)D was 21 (14-36) nmol/l [8(6-15) ng/ml] in cord blood, and 46 (37-60) nmol/l [18(15-24) ng/ml] at discharge. Serum 25(OH)D was &lt;50nmol/L in 71,3% of mothers, in 91,5% of cord blood samples, and in almost 60% of preterm newborns at discharge (after 8 weeks of supplementation). Serum 25(OH)D was &lt;75 nmol/L in 88,3% of mothers, in 97,9% of cord blood samples, and in 91,4% of preterm newborns at discharge. In our cohort, we found that due to the very high prevalence of 25(OH)D deficiency among mothers, the current generally recommended dose of vitamin D (800-1000IU per day) for VLBW infants was unable to improve vitamin D levels above the desired 50 or even 75 nmol/L before discharge.

Název v anglickém jazyce

Vitamin D status of very low birth weight infants at birth and the effects of generally recommended supplementation on their vitamin D levels at discharge

Popis výsledku anglicky

To evaluate vitamin D status in mothers and their very low birth weight infants (VLBW) at birth (umbilical cord blood) and at discharge with currently recommended supplementation of vitamin D. Ninety-four infants with birth weight less than 1500 g completed the study. The total daily vitamin D intake was 800-1000 IU. We examined 25-hydroxyvitamin-D [25(OH)D] levels in maternal serum before labor, in cord blood, and in infants&apos;serum at discharge. Median (IQR) serum 25(OH)D was 21 (14-36) nmol/l [8(6-15) ng/ml] in cord blood, and 46 (37-60) nmol/l [18(15-24) ng/ml] at discharge. Serum 25(OH)D was &lt;50nmol/L in 71,3% of mothers, in 91,5% of cord blood samples, and in almost 60% of preterm newborns at discharge (after 8 weeks of supplementation). Serum 25(OH)D was &lt;75 nmol/L in 88,3% of mothers, in 97,9% of cord blood samples, and in 91,4% of preterm newborns at discharge. In our cohort, we found that due to the very high prevalence of 25(OH)D deficiency among mothers, the current generally recommended dose of vitamin D (800-1000IU per day) for VLBW infants was unable to improve vitamin D levels above the desired 50 or even 75 nmol/L before discharge.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30209 - Paediatrics

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

The Journal of Maternal-Fetal &amp; Neonatal Medicine

ISSN

1476-7058

e-ISSN

—

Svazek periodika

33

Číslo periodika v rámci svazku

22

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

3784-3790

Kód UT WoS článku

000570229600010

EID výsledku v databázi Scopus

2-s2.0-85063030998