Alarmins HMGB1, IL-33, S100A7, and S100A12 in Psoriasis Vulgaris

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F20%3A10411353" target="_blank" >RIV/00216208:11150/20:10411353 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/20:10411353

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=FU-un1ue2i" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=FU-un1ue2i</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2020/8465083" target="_blank" >10.1155/2020/8465083</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Alarmins HMGB1, IL-33, S100A7, and S100A12 in Psoriasis Vulgaris

Popis výsledku v původním jazyce

Background. Psoriasis vulgaris is a chronic autoimmune disease associated with systemic inflammation. Increased levels of numerous cytokines, chemokines, growth factors, and other molecules were found in the skin and in the circulation of psoriatic patients. Alarmins, also known as danger signals, are intracellular proteins, which are released to an extracellular space after infection or damage. They are the markers of cell destructive processes. Objective. The aim of the present study was to evaluate the suitability of selected alarmins (HMGB1, IL-33, S100A7, and S100A12) as potential biomarkers of severity of psoriasis and to explore possible relationships between these proteins for the purpose of better understanding their roles in the immunopathology of psoriasis. Methods. The serum levels of selected alarmins were measured in 63 psoriatic patients and 95 control individuals. The levels were assessed by the ELISA technique using commercial kits. The data were statistically processed with MedCalc version 19.0.5. Results. In psoriatic patients, we found significantly increased levels of HMGB1 (p&lt;0.05), IL-33 (p&lt;0.01), S100A7 (p&lt;0.0001), and S100A12 (p&lt;0.0001). In addition, we found a significant relationship between HMGB1 and S100A7 (Spearman&apos;s rho=0.276, p&lt;0.05) in the patients and significant relationship between HMGB1 and IL-33 in the controls (Spearman&apos;s rho=0.416, p&lt;0.05). We did not find any relationship between observed alarmins and the disease severity. Conclusions. The alarmins HMGB1, IL-33, S100A7, and S100A12 were significantly elevated in the serum of patients, which states the hypothesis that they play specific roles in the immunopathology of psoriasis. However, we have not yet found a relationship between observed alarmins and the disease severity. The discovery of the relationship between HMGB1 and S100A7 is a novelty that should be studied in the future to further clarify its role and importance.

Název v anglickém jazyce

Alarmins HMGB1, IL-33, S100A7, and S100A12 in Psoriasis Vulgaris

Popis výsledku anglicky

Background. Psoriasis vulgaris is a chronic autoimmune disease associated with systemic inflammation. Increased levels of numerous cytokines, chemokines, growth factors, and other molecules were found in the skin and in the circulation of psoriatic patients. Alarmins, also known as danger signals, are intracellular proteins, which are released to an extracellular space after infection or damage. They are the markers of cell destructive processes. Objective. The aim of the present study was to evaluate the suitability of selected alarmins (HMGB1, IL-33, S100A7, and S100A12) as potential biomarkers of severity of psoriasis and to explore possible relationships between these proteins for the purpose of better understanding their roles in the immunopathology of psoriasis. Methods. The serum levels of selected alarmins were measured in 63 psoriatic patients and 95 control individuals. The levels were assessed by the ELISA technique using commercial kits. The data were statistically processed with MedCalc version 19.0.5. Results. In psoriatic patients, we found significantly increased levels of HMGB1 (p&lt;0.05), IL-33 (p&lt;0.01), S100A7 (p&lt;0.0001), and S100A12 (p&lt;0.0001). In addition, we found a significant relationship between HMGB1 and S100A7 (Spearman&apos;s rho=0.276, p&lt;0.05) in the patients and significant relationship between HMGB1 and IL-33 in the controls (Spearman&apos;s rho=0.416, p&lt;0.05). We did not find any relationship between observed alarmins and the disease severity. Conclusions. The alarmins HMGB1, IL-33, S100A7, and S100A12 were significantly elevated in the serum of patients, which states the hypothesis that they play specific roles in the immunopathology of psoriasis. However, we have not yet found a relationship between observed alarmins and the disease severity. The discovery of the relationship between HMGB1 and S100A7 is a novelty that should be studied in the future to further clarify its role and importance.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mediators of Inflammation

ISSN

0962-9351

e-ISSN

—

Svazek periodika

2020

Číslo periodika v rámci svazku

APR

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

8465083

Kód UT WoS článku

000530369300004

EID výsledku v databázi Scopus

2-s2.0-85084391891