Different Forms of Ursolic Acid and Their Effect on liver Regeneration

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F20%3A10414237" target="_blank" >RIV/00216208:11150/20:10414237 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/20:10414237

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=lW_9kvI-DQ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=lW_9kvI-DQ</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2020/4074068" target="_blank" >10.1155/2020/4074068</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Different Forms of Ursolic Acid and Their Effect on liver Regeneration

Popis výsledku v původním jazyce

The aim of this study was to determine the effect of natural and encapsulated sources of ursolic acid on liver regeneration. Four ursolate sources were tested. Two forms of ursolic acid encapsulates combined with cyclodextrins, i.e. gamma-CD (gCD) and beta-CD; and two natural sources adjusted by homogenization (HAP) and micronization of apple peel using Jonagold apples. All ursolate forms were applied intragastrically in daily doses of 20 mg for 7 days. Laboratory rats were fed with standard laboratory diet. Further, gCD and MAP were also tested with a high fat diet (6 weeks). Partial hepatectomy (PH) was performed 24 hours before the end of the experiment. The concentration of plasma hepatocyte growth factor (HGF) was determined with an immunoassay; simultaneously, the expression of HGF and CYP7A1 in liver was quantified through qPCR. HGF expression and plasma levels were significantly increased 24 hours after PH in both the HAP (p = 0.038) and HFgCD groups (p = 0.036), respectively. The correlation between HGF expression and plasma values was significant (p = 0.04). The positive effects on liver regeneration were found in both the gCD and HAP forms of ursolic acid, whose effects were confirmed through the upregulation of HGF.

Název v anglickém jazyce

Different Forms of Ursolic Acid and Their Effect on liver Regeneration

Popis výsledku anglicky

The aim of this study was to determine the effect of natural and encapsulated sources of ursolic acid on liver regeneration. Four ursolate sources were tested. Two forms of ursolic acid encapsulates combined with cyclodextrins, i.e. gamma-CD (gCD) and beta-CD; and two natural sources adjusted by homogenization (HAP) and micronization of apple peel using Jonagold apples. All ursolate forms were applied intragastrically in daily doses of 20 mg for 7 days. Laboratory rats were fed with standard laboratory diet. Further, gCD and MAP were also tested with a high fat diet (6 weeks). Partial hepatectomy (PH) was performed 24 hours before the end of the experiment. The concentration of plasma hepatocyte growth factor (HGF) was determined with an immunoassay; simultaneously, the expression of HGF and CYP7A1 in liver was quantified through qPCR. HGF expression and plasma levels were significantly increased 24 hours after PH in both the HAP (p = 0.038) and HFgCD groups (p = 0.036), respectively. The correlation between HGF expression and plasma values was significant (p = 0.04). The positive effects on liver regeneration were found in both the gCD and HAP forms of ursolic acid, whose effects were confirmed through the upregulation of HGF.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Evidence-based Complementary and Alternative Medicine

ISSN

1741-427X

e-ISSN

—

Svazek periodika

2020

Číslo periodika v rámci svazku

JUL

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

4074068

Kód UT WoS článku

000561811900002

EID výsledku v databázi Scopus

2-s2.0-85089570041