Histopathological changes in dilated ascending aorta associated with aortic valve cuspidity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F21%3A10419041" target="_blank" >RIV/00216208:11150/21:10419041 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/21:10419041

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JmjKWnx.UP" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JmjKWnx.UP</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/ejcts/ezaa440" target="_blank" >10.1093/ejcts/ezaa440</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Histopathological changes in dilated ascending aorta associated with aortic valve cuspidity

Popis výsledku v původním jazyce

Abstract Objectives: Patients with a bicuspid aortic valve (BAV) often present with a dilated ascending aorta. However, the underlying pathogenesis for the observed changes in the aortic wall and the resulting aneurysmal dilation remains a subject of debate. This study aims to compare the histological abnormalities of the ascending aorta in BAV and tricuspid aortic valve (TAV) patients and their correlation with aortic diameter and patient age. Methods: A total of 376 patients from our institution&apos;s clinical database were included in the retrospective analysis. These patients underwent either elective surgery for ascending aorta dilation or emergency surgery for aortic dissection, either isolated or with a structurally diseased aortic valve. After excision, the ascending aorta samples were analysed by a pathologist. Results: On histological examination, a higher degree of elastic fibre fragmentation and loss and mucoid extracellular matrix accumulation was present in the samples from TAV patients when compared with that from BAV patients (P &lt; 0.001). However, correlation was poor for all variables when considering aortic diameter and histological abnormalities or age and histological abnormalities in both BAV and TAV patients. Conclusions: Our study demonstrates a greater incidence of severe histological abnormalities in TAV patients when compared with BAV patients.

Název v anglickém jazyce

Histopathological changes in dilated ascending aorta associated with aortic valve cuspidity

Popis výsledku anglicky

Abstract Objectives: Patients with a bicuspid aortic valve (BAV) often present with a dilated ascending aorta. However, the underlying pathogenesis for the observed changes in the aortic wall and the resulting aneurysmal dilation remains a subject of debate. This study aims to compare the histological abnormalities of the ascending aorta in BAV and tricuspid aortic valve (TAV) patients and their correlation with aortic diameter and patient age. Methods: A total of 376 patients from our institution&apos;s clinical database were included in the retrospective analysis. These patients underwent either elective surgery for ascending aorta dilation or emergency surgery for aortic dissection, either isolated or with a structurally diseased aortic valve. After excision, the ascending aorta samples were analysed by a pathologist. Results: On histological examination, a higher degree of elastic fibre fragmentation and loss and mucoid extracellular matrix accumulation was present in the samples from TAV patients when compared with that from BAV patients (P &lt; 0.001). However, correlation was poor for all variables when considering aortic diameter and histological abnormalities or age and histological abnormalities in both BAV and TAV patients. Conclusions: Our study demonstrates a greater incidence of severe histological abnormalities in TAV patients when compared with BAV patients.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Cardio-Thoracic Surgery

ISSN

1010-7940

e-ISSN

—

Svazek periodika

59

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

1103-1108

Kód UT WoS článku

000661342500024

EID výsledku v databázi Scopus

2-s2.0-85106537779