Cardiac doses of accelerated partial breast irradiation with perioperative multicatheter interstitial brachytherapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F21%3A10423515" target="_blank" >RIV/00216208:11150/21:10423515 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/21:10423515

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=-TIZBTfF4I" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=-TIZBTfF4I</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00066-020-01699-5" target="_blank" >10.1007/s00066-020-01699-5</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cardiac doses of accelerated partial breast irradiation with perioperative multicatheter interstitial brachytherapy

Popis výsledku v původním jazyce

Purpose To quantify mean heart dose (MHD) and doses to the left anterior descending artery (LAD) and left ventricle (LV) in a retrospective series of patients who underwent perioperative accelerated partial breast irradiation with multicatheter interstitial brachytherapy (MIB-APBI). Methods Sixty-eight patients with low-risk left breast cancer were treated with MIB-APBI at our institution between 2012 and 2017. Interstitial tubes were inserted during the tumorectomy and sentinel node biopsy and APBI was started 6 days later. The prescribed dose was 34Gy in 10 fractions (twice a day) to the clinical target volume (CTV). The heart, LAD, and LV were contoured and the distance between each structure and the CTV was measured. The MHD, mean and maximum LAD doses (LAD mean/max), and mean LV doses (LV mean) were calculated and corrected to biologically equivalent doses in 2-Gy fractionation (EQD2). We also evaluated the impact of the distance between the cardiac structures and the CTV and of the volume receiving the prescribed dose (V100) and high-dose volume (V150) on heart dosimetry. Results Mean EQD2 for MHD, LAD mean/max, and mean LV were 0.9 +/- 0.4Gy (range 0.3-2.2), 1.6 +/- 1.1Gy (range, 0.4-5.6), 2.6 +/- 1.9Gy (range, 0.7-9.2), and 1.3 +/- 0.6Gy (range, 0.5-3.4), respectively. MHD, LAD mean/max, and LV mean significantly correlated with the distance between the CTV and these structures, but all doses were below the recommended limits (German Society of Radiation Oncology; DEGRO). The MHD and LV mean were significantly dependent on V100. Conclusion Perioperative MIB-APBI resulted in low cardiac doses in our study. This finding provides further support for the value of this technique in well-selected patients with early-stage left breast cancer.

Název v anglickém jazyce

Cardiac doses of accelerated partial breast irradiation with perioperative multicatheter interstitial brachytherapy

Popis výsledku anglicky

Purpose To quantify mean heart dose (MHD) and doses to the left anterior descending artery (LAD) and left ventricle (LV) in a retrospective series of patients who underwent perioperative accelerated partial breast irradiation with multicatheter interstitial brachytherapy (MIB-APBI). Methods Sixty-eight patients with low-risk left breast cancer were treated with MIB-APBI at our institution between 2012 and 2017. Interstitial tubes were inserted during the tumorectomy and sentinel node biopsy and APBI was started 6 days later. The prescribed dose was 34Gy in 10 fractions (twice a day) to the clinical target volume (CTV). The heart, LAD, and LV were contoured and the distance between each structure and the CTV was measured. The MHD, mean and maximum LAD doses (LAD mean/max), and mean LV doses (LV mean) were calculated and corrected to biologically equivalent doses in 2-Gy fractionation (EQD2). We also evaluated the impact of the distance between the cardiac structures and the CTV and of the volume receiving the prescribed dose (V100) and high-dose volume (V150) on heart dosimetry. Results Mean EQD2 for MHD, LAD mean/max, and mean LV were 0.9 +/- 0.4Gy (range 0.3-2.2), 1.6 +/- 1.1Gy (range, 0.4-5.6), 2.6 +/- 1.9Gy (range, 0.7-9.2), and 1.3 +/- 0.6Gy (range, 0.5-3.4), respectively. MHD, LAD mean/max, and LV mean significantly correlated with the distance between the CTV and these structures, but all doses were below the recommended limits (German Society of Radiation Oncology; DEGRO). The MHD and LV mean were significantly dependent on V100. Conclusion Perioperative MIB-APBI resulted in low cardiac doses in our study. This finding provides further support for the value of this technique in well-selected patients with early-stage left breast cancer.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Strahlentherapie und Onkologie

ISSN

0179-7158

e-ISSN

—

Svazek periodika

197

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

8

Strana od-do

288-295

Kód UT WoS článku

000579308100001

EID výsledku v databázi Scopus

2-s2.0-85092675167