Acute Management Should Be Optimized in Patients with Less Specific Stroke Symptoms: Findings from a Retrospective Observational Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F21%3A10426167" target="_blank" >RIV/00216208:11150/21:10426167 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/21:10426167

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=sds674IV1p" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=sds674IV1p</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/jcm10051143" target="_blank" >10.3390/jcm10051143</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Acute Management Should Be Optimized in Patients with Less Specific Stroke Symptoms: Findings from a Retrospective Observational Study

Popis výsledku v původním jazyce

Anterior circulation stroke (ACS) is associated with typical symptoms, while posterior circulation stroke (PCS) may cause a wide spectrum of less specific symptoms. We aim to assess the correlation between the initial presentation of acute ischemic stroke (AIS) symptoms and the treatment timeline. Using a retrospective, observational, single-center study, the set consists of 809 AIS patients treated with intravenous thrombolysis (IVT) and/or endovascular treatment (EVT). We investigate the impact of baseline clinical AIS symptoms and the affected vascular territory on recanalization times in patients treated with IVT only and EVT (+/- IVT). Regarding the IVT-only group, increasing the National Institutes of Health Stroke Scale (NIHSS) score on admission and speech difficulties are associated with shorter (by 1.59 +/- 0.76 min per every one-point increase; p = 0.036, and by 24.56 +/- 8.42 min; p = 0.004, respectively) and nausea/vomiting with longer (by 43.72 +/- 13.13 min; p = 0.001) onset-to-needle times, and vertigo with longer (by 8.58 +/- 3.84 min; p = 0.026) door-to-needle times (DNT). Regarding the EVT (+/- IVT) group, coma is associated with longer (by 22.68 +/- 6.05 min; p = 0.0002) DNT, anterior circulation stroke with shorter (by 47.32 +/- 16.89 min; p = 0.005) onset-to-groin time, and drooping of the mouth corner with shorter (by 20.79 +/- 6.02 min; p = 0.0006) door-to-groin time. Our results demonstrate that treatment is initiated later in strokes with less specific symptoms than in strokes with typical symptoms.

Název v anglickém jazyce

Acute Management Should Be Optimized in Patients with Less Specific Stroke Symptoms: Findings from a Retrospective Observational Study

Popis výsledku anglicky

Anterior circulation stroke (ACS) is associated with typical symptoms, while posterior circulation stroke (PCS) may cause a wide spectrum of less specific symptoms. We aim to assess the correlation between the initial presentation of acute ischemic stroke (AIS) symptoms and the treatment timeline. Using a retrospective, observational, single-center study, the set consists of 809 AIS patients treated with intravenous thrombolysis (IVT) and/or endovascular treatment (EVT). We investigate the impact of baseline clinical AIS symptoms and the affected vascular territory on recanalization times in patients treated with IVT only and EVT (+/- IVT). Regarding the IVT-only group, increasing the National Institutes of Health Stroke Scale (NIHSS) score on admission and speech difficulties are associated with shorter (by 1.59 +/- 0.76 min per every one-point increase; p = 0.036, and by 24.56 +/- 8.42 min; p = 0.004, respectively) and nausea/vomiting with longer (by 43.72 +/- 13.13 min; p = 0.001) onset-to-needle times, and vertigo with longer (by 8.58 +/- 3.84 min; p = 0.026) door-to-needle times (DNT). Regarding the EVT (+/- IVT) group, coma is associated with longer (by 22.68 +/- 6.05 min; p = 0.0002) DNT, anterior circulation stroke with shorter (by 47.32 +/- 16.89 min; p = 0.005) onset-to-groin time, and drooping of the mouth corner with shorter (by 20.79 +/- 6.02 min; p = 0.0006) door-to-groin time. Our results demonstrate that treatment is initiated later in strokes with less specific symptoms than in strokes with typical symptoms.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Clinical Medicine [online]

ISSN

2077-0383

e-ISSN

—

Svazek periodika

10

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

13

Strana od-do

1143

Kód UT WoS článku

000628244300001

EID výsledku v databázi Scopus

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