The anticancer properties of harmine and its derivatives

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F25%3A10486002" target="_blank" >RIV/00216208:11150/25:10486002 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11160/25:10486002

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=MOY~8PIrg8" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=MOY~8PIrg8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11101-024-09978-0" target="_blank" >10.1007/s11101-024-09978-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The anticancer properties of harmine and its derivatives

Popis výsledku v původním jazyce

This review aims to provide information about the anticancer potential of harmine, a beta-carboline alkaloid that was initially isolated in 1847 from the seeds and roots of Peganum harmala L. Various studies have revealed that it possesses a wide range of therapeutic qualities, including anti-inflammatory, antibacterial, antiviral, antidiabetic, and, most notably, anticancer effects. This review discusses the anticancer capabilities of harmine and its derivatives against malignancies such as breast cancer, lung cancer, gastric cancer, colon cancer, glioblastoma, neuroblastoma, liver cancer, pancreatic cancer and thyroid cancer. Harmine uses mechanisms such as apoptosis and angiogenesis inhibition to fight cancer cells. It also influences the cell cycle by inhibiting specific cyclin-dependent kinases and slowing tumor cell proliferation. Synergistic effects have also been observed when harmine is used in combination with other anticancer medications. Harmine has the potential to be a potent anticancer medication that can help in the fight against cancer.

Název v anglickém jazyce

The anticancer properties of harmine and its derivatives

Popis výsledku anglicky

This review aims to provide information about the anticancer potential of harmine, a beta-carboline alkaloid that was initially isolated in 1847 from the seeds and roots of Peganum harmala L. Various studies have revealed that it possesses a wide range of therapeutic qualities, including anti-inflammatory, antibacterial, antiviral, antidiabetic, and, most notably, anticancer effects. This review discusses the anticancer capabilities of harmine and its derivatives against malignancies such as breast cancer, lung cancer, gastric cancer, colon cancer, glioblastoma, neuroblastoma, liver cancer, pancreatic cancer and thyroid cancer. Harmine uses mechanisms such as apoptosis and angiogenesis inhibition to fight cancer cells. It also influences the cell cycle by inhibiting specific cyclin-dependent kinases and slowing tumor cell proliferation. Synergistic effects have also been observed when harmine is used in combination with other anticancer medications. Harmine has the potential to be a potent anticancer medication that can help in the fight against cancer.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Phytochemistry Reviews

ISSN

1568-7767

e-ISSN

1572-980X

Svazek periodika

24

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

30

Strana od-do

1535-1564

Kód UT WoS článku

001314852800002

EID výsledku v databázi Scopus

2-s2.0-85204352606