Antiviral Activity of Substituted Salicylanilides - A Review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F11%3A10099476" target="_blank" >RIV/00216208:11160/11:10099476 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.ingentaconnect.com/content/ben/mrmc/2011/00000011/00000011/art00003" target="_blank" >http://www.ingentaconnect.com/content/ben/mrmc/2011/00000011/00000011/art00003</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Antiviral Activity of Substituted Salicylanilides - A Review

Popis výsledku v původním jazyce

Salicylanilides demonstrated a wide range of biological activities including antiviral potency and the review summarizes this field. Niclosamide was described to be able to affect coronaviruses. Some salicylanilides and salicylamides could inhibit HIV virus by targeting of HIV-1 integrase or reverse transcriptase. Hepatitis C virus is another virus, which could be potentially afflicted by salicylanilides on the level of two enzymes - NS3 protease and NS5B RNA polymerase. Nitazoxanide is a nitrothiazolederivative of salicylamide useful for the treatment of protozoal and bacterial infections with an extended range of antiviral activity and innovative mechanism of action, especially against hepatitis and influenza viruses or rotaviruses. Nitazoxanide, its metabolite tizoxanide and their derivatives are a very promising stream in the development of new antiviral compounds. In this review, we summarize the antiviral activity of structures containing salicylanilide and partly salicylamide m

Název v anglickém jazyce

Antiviral Activity of Substituted Salicylanilides - A Review

Popis výsledku anglicky

Salicylanilides demonstrated a wide range of biological activities including antiviral potency and the review summarizes this field. Niclosamide was described to be able to affect coronaviruses. Some salicylanilides and salicylamides could inhibit HIV virus by targeting of HIV-1 integrase or reverse transcriptase. Hepatitis C virus is another virus, which could be potentially afflicted by salicylanilides on the level of two enzymes - NS3 protease and NS5B RNA polymerase. Nitazoxanide is a nitrothiazolederivative of salicylamide useful for the treatment of protozoal and bacterial infections with an extended range of antiviral activity and innovative mechanism of action, especially against hepatitis and influenza viruses or rotaviruses. Nitazoxanide, its metabolite tizoxanide and their derivatives are a very promising stream in the development of new antiviral compounds. In this review, we summarize the antiviral activity of structures containing salicylanilide and partly salicylamide m

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/NS10367" target="_blank" >NS10367: Hodnocení a vývoj nových perspektivních antituberkulotik a jejich proléčiv aktivních vůči multirezistentním kmenům</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mini reviews in medicinal chemistry

ISSN

1389-5575

e-ISSN

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Svazek periodika

11

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

12

Strana od-do

956-967

Kód UT WoS článku

000294704600003

EID výsledku v databázi Scopus

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