Study on 99mTc-MAG3 and 99mTc-DMSA renal accumulation using in vitro cellular model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F11%3A10100471" target="_blank" >RIV/00216208:11160/11:10100471 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.prolekare.cz/ceska-slovenska-farmacie-clanek?id=34296" target="_blank" >http://www.prolekare.cz/ceska-slovenska-farmacie-clanek?id=34296</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Study on 99mTc-MAG3 and 99mTc-DMSA renal accumulation using in vitro cellular model

Popis výsledku v původním jazyce

99mTc-MAG3 and 99mTc-DMSA are renal radiodiagnostics in clinical use. However, the renal mechanisms determining their transport within the kidney are not fully explained. The investigation compared renal uptake of the studied compounds and evaluated contribution of active and passive transport mechanisms to the renal accumulation. As the experimental model, freshly isolated rat renal cells were used. The results documented significant quantitative and qualitative differences between the tested agents. The found data indicated that 99mTc-DMSA was transported across the membranes of the renal cells almost exclusively by passive transport. On the other side, 99mTc-MAG3 accumulation rate in the rat renal cells was several times higher and was mediated by active transport mechanisms.

Název v anglickém jazyce

Study on 99mTc-MAG3 and 99mTc-DMSA renal accumulation using in vitro cellular model

Popis výsledku anglicky

99mTc-MAG3 and 99mTc-DMSA are renal radiodiagnostics in clinical use. However, the renal mechanisms determining their transport within the kidney are not fully explained. The investigation compared renal uptake of the studied compounds and evaluated contribution of active and passive transport mechanisms to the renal accumulation. As the experimental model, freshly isolated rat renal cells were used. The results documented significant quantitative and qualitative differences between the tested agents. The found data indicated that 99mTc-DMSA was transported across the membranes of the renal cells almost exclusively by passive transport. On the other side, 99mTc-MAG3 accumulation rate in the rat renal cells was several times higher and was mediated by active transport mechanisms.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Česká a slovenská farmacie

ISSN

1210-7816

e-ISSN

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Svazek periodika

60

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

4

Strana od-do

7-10

Kód UT WoS článku

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EID výsledku v databázi Scopus

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