Preclinical Evaluation of Wound Treatment with Hyaluronan-Iodine Hydrogel

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F12%3A10124671" target="_blank" >RIV/00216208:11160/12:10124671 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.woundsresearch.com/article/preclinical-evaluation-wound-treatment-hyaluronan-iodine-hydrogel" target="_blank" >http://www.woundsresearch.com/article/preclinical-evaluation-wound-treatment-hyaluronan-iodine-hydrogel</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Preclinical Evaluation of Wound Treatment with Hyaluronan-Iodine Hydrogel

Popis výsledku v původním jazyce

A mixture of hyaluronan and iodine complex Kl(3) (Hyiodine (R)) has been developed to support wound healing. In this study, the effect of hyaluronan, Kl(3), and their combination on progression of wound healing in excision skin wounds in rats was determined. Methods. To evaluate the possible toxic effects of iodine after Hyiodine application for wound healing, iodine systemic absorption from the Hyiodine-treated wounds and its distribution profile were quantitatively described and compared after intravenous iodide administration using I-131 as a radiolabel. Results. Treatment of rats with Hyiodine resulted in an enhancement of wound healing, proved by greater degrees of wound contraction and reduction in mean wound healing time compared to other treated rats on hours 1, 2, 24, and 216. Even if wound therapy with Hyiodine resulted in systemic iodine uptake, the estimated iodine absorbed dose in human therapy is tolerable, and the theoretical risk of its systemic toxic effects is minimal

Název v anglickém jazyce

Preclinical Evaluation of Wound Treatment with Hyaluronan-Iodine Hydrogel

Popis výsledku anglicky

A mixture of hyaluronan and iodine complex Kl(3) (Hyiodine (R)) has been developed to support wound healing. In this study, the effect of hyaluronan, Kl(3), and their combination on progression of wound healing in excision skin wounds in rats was determined. Methods. To evaluate the possible toxic effects of iodine after Hyiodine application for wound healing, iodine systemic absorption from the Hyiodine-treated wounds and its distribution profile were quantitatively described and compared after intravenous iodide administration using I-131 as a radiolabel. Results. Treatment of rats with Hyiodine resulted in an enhancement of wound healing, proved by greater degrees of wound contraction and reduction in mean wound healing time compared to other treated rats on hours 1, 2, 24, and 216. Even if wound therapy with Hyiodine resulted in systemic iodine uptake, the estimated iodine absorbed dose in human therapy is tolerable, and the theoretical risk of its systemic toxic effects is minimal

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FJ - Chirurgie včetně transplantologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Wounds

ISSN

1044-7946

e-ISSN

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Svazek periodika

24

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

267-274

Kód UT WoS článku

000308778300006

EID výsledku v databázi Scopus

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