Antimycobacterial Activity of Quaternary Pyridinium Salts and Pyridinium N-oxides - Review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F13%3A10145615" target="_blank" >RIV/00216208:11160/13:10145615 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.ingentaconnect.com/content/ben/cpd/2013/00000019/00000007/art00018" target="_blank" >http://www.ingentaconnect.com/content/ben/cpd/2013/00000019/00000007/art00018</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/138161213804805711" target="_blank" >10.2174/138161213804805711</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Antimycobacterial Activity of Quaternary Pyridinium Salts and Pyridinium N-oxides - Review

Popis výsledku v původním jazyce

The treatment of tuberculosis and other mycobacterioses is still a major world health problem and new antimycobacterial compounds unrelated to approved drugs are in demand. Quaternary ammonium salts have revealed many usable properties especially as antimicrobials; they are widely used as disinfection and antiseptic agents. Some of these compounds, including pyridinium salts, have revealed substantial antimycobacterial action, although the presence of the cationic nitrogen itself is not sufficient for activity. A long N-alkyl chain is also not necessary for antimycobacterial activity, although it is associated with improved activity. Compounds that have shown significant in vitro activity, e. g., cetylpyridinium, N-(substituted alkyl) pyridinium salts,3-[(5-cyclopentylpentyl)(substituted phenyl) amino]-1-methylpyridinium iodides or pyridinium alkyl ethers of steroids (good activity with minimum inhibitory concentrations - MIC from 0.4 mu g/mL). However, most pyridinium salts have mild

Název v anglickém jazyce

Antimycobacterial Activity of Quaternary Pyridinium Salts and Pyridinium N-oxides - Review

Popis výsledku anglicky

The treatment of tuberculosis and other mycobacterioses is still a major world health problem and new antimycobacterial compounds unrelated to approved drugs are in demand. Quaternary ammonium salts have revealed many usable properties especially as antimicrobials; they are widely used as disinfection and antiseptic agents. Some of these compounds, including pyridinium salts, have revealed substantial antimycobacterial action, although the presence of the cationic nitrogen itself is not sufficient for activity. A long N-alkyl chain is also not necessary for antimycobacterial activity, although it is associated with improved activity. Compounds that have shown significant in vitro activity, e. g., cetylpyridinium, N-(substituted alkyl) pyridinium salts,3-[(5-cyclopentylpentyl)(substituted phenyl) amino]-1-methylpyridinium iodides or pyridinium alkyl ethers of steroids (good activity with minimum inhibitory concentrations - MIC from 0.4 mu g/mL). However, most pyridinium salts have mild

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Pharmaceutical Design

ISSN

1381-6128

e-ISSN

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Svazek periodika

19

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

TR - Turecká republika

Počet stran výsledku

13

Strana od-do

1343-1355

Kód UT WoS článku

000316451800018

EID výsledku v databázi Scopus

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