Separation and determination of chlorophenylpiperazine isomers in confiscated pills by capillary electrophoresis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F13%3A10145755" target="_blank" >RIV/00216208:11160/13:10145755 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0731708513002434" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0731708513002434</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jpba.2013.05.042" target="_blank" >10.1016/j.jpba.2013.05.042</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Separation and determination of chlorophenylpiperazine isomers in confiscated pills by capillary electrophoresis

Popis výsledku v původním jazyce

A simple capillary electrophoretic method with spectrophotometric UV detection at 236 nm has been developed for the selective separation and determination of 1-(2-chlorophenyl)piperazine (oCPP), 1-(3-chlorophenyl)piperazine (mCPP) and 1-(4-chlorophenyl)piperazine (pCPP) in confiscated pills. Several cyclodextrin derivatives were tested to compose the background electrolyte (BGE). The optimized BGE contained 20 mmol/L phosphoric acid adjusted to pH 2.5 with triethylamine and 10 mmol/L alpha-cyclodextrin,which provided acceptable resolution of analytes and candidate interferents in less. than 15 min. The analyses were performed at constant voltage of 25 kV in 60 cm (effective length 50 cm; 50 mu m i.d.) uncoated fused-silica capillary maintained at 25 Cwith sample injection at 4826 Pa for 8s. Procaine at a concentration of 0.1 mg/mL was used as internal standard (IS). Possible interference from other drugs such as amphetamine, methamphetamine, 3,4-methylenedioxyaniphetamine, 3,4-methyl

Název v anglickém jazyce

Separation and determination of chlorophenylpiperazine isomers in confiscated pills by capillary electrophoresis

Popis výsledku anglicky

A simple capillary electrophoretic method with spectrophotometric UV detection at 236 nm has been developed for the selective separation and determination of 1-(2-chlorophenyl)piperazine (oCPP), 1-(3-chlorophenyl)piperazine (mCPP) and 1-(4-chlorophenyl)piperazine (pCPP) in confiscated pills. Several cyclodextrin derivatives were tested to compose the background electrolyte (BGE). The optimized BGE contained 20 mmol/L phosphoric acid adjusted to pH 2.5 with triethylamine and 10 mmol/L alpha-cyclodextrin,which provided acceptable resolution of analytes and candidate interferents in less. than 15 min. The analyses were performed at constant voltage of 25 kV in 60 cm (effective length 50 cm; 50 mu m i.d.) uncoated fused-silica capillary maintained at 25 Cwith sample injection at 4826 Pa for 8s. Procaine at a concentration of 0.1 mg/mL was used as internal standard (IS). Possible interference from other drugs such as amphetamine, methamphetamine, 3,4-methylenedioxyaniphetamine, 3,4-methyl

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Pharmaceutical and Biomedical Analysis

ISSN

0731-7085

e-ISSN

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Svazek periodika

84

Číslo periodika v rámci svazku

October

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

140-147

Kód UT WoS článku

000322752800021

EID výsledku v databázi Scopus

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