The Chemistry and Biology of 6-Hydroxyceramide, the Youngest Member of the Human Sphingolipid Family

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F14%3A10281636" target="_blank" >RIV/00216208:11160/14:10281636 - isvavai.cz</a>

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1002/cbic.201402153/full" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/cbic.201402153/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/cbic.201402153" target="_blank" >10.1002/cbic.201402153</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The Chemistry and Biology of 6-Hydroxyceramide, the Youngest Member of the Human Sphingolipid Family

Popis výsledku v původním jazyce

Sphingolipids are crucial for the life of the cell. In land-dwelling mammals, they are equally important outside the cell-in the extracellular space of the skin barrier-because they prevent loss of water. Although a large body of research has elucidatedmany of the functions of sphingolipids, their extensive structural diversity remains intriguing. A new class of sphingolipids based on 6-hydroxylated sphingosine has recently been identified in human skin. Abnormal levels of these 6-hydroxylated ceramides have repeatedly been observed in atopic dermatitis; however, neither the biosynthesis nor the roles of these unique ceramide subclasses have been established in the human body. In this Minireview, we summarize the current knowledge of 6-hydroxyceramides, including their discovery, structure, stereochemistry, occurrence in healthy and diseased human epidermis, and synthetic approaches to 6-hydroxysphingosine and related ceramides.

Název v anglickém jazyce

The Chemistry and Biology of 6-Hydroxyceramide, the Youngest Member of the Human Sphingolipid Family

Popis výsledku anglicky

Sphingolipids are crucial for the life of the cell. In land-dwelling mammals, they are equally important outside the cell-in the extracellular space of the skin barrier-because they prevent loss of water. Although a large body of research has elucidatedmany of the functions of sphingolipids, their extensive structural diversity remains intriguing. A new class of sphingolipids based on 6-hydroxylated sphingosine has recently been identified in human skin. Abnormal levels of these 6-hydroxylated ceramides have repeatedly been observed in atopic dermatitis; however, neither the biosynthesis nor the roles of these unique ceramide subclasses have been established in the human body. In this Minireview, we summarize the current knowledge of 6-hydroxyceramides, including their discovery, structure, stereochemistry, occurrence in healthy and diseased human epidermis, and synthetic approaches to 6-hydroxysphingosine and related ceramides.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/GA13-23891S" target="_blank" >GA13-23891S: Modely lipidových membrán - nový nástroj pro studium patofyziologie kožních onemocnění na molekulární úrovni</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ChemBioChem

ISSN

1439-4227

e-ISSN

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Svazek periodika

15

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

8

Strana od-do

1555-1562

Kód UT WoS článku

000339502900002

EID výsledku v databázi Scopus

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