Retention and selectivity of basic drugs on solid-phase extraction sorbents: Application to direct determination of beta-blockers in urine

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F14%3A10281834" target="_blank" >RIV/00216208:11160/14:10281834 - isvavai.cz</a>

Výsledek na webu

<a href="http://link.springer.com/article/10.1007/s00216-014-7753-4/fulltext.html" target="_blank" >http://link.springer.com/article/10.1007/s00216-014-7753-4/fulltext.html</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00216-014-7753-4" target="_blank" >10.1007/s00216-014-7753-4</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Retention and selectivity of basic drugs on solid-phase extraction sorbents: Application to direct determination of beta-blockers in urine

Popis výsledku v původním jazyce

Seven solid phase sorbent materials with reversed-phase, mixed-mode interactions (ion-exchange and reversed-phase), and molecularly imprinted polymers (MIP), namely Oasis HLB, Oasis MAX, Oasis MCX, Bond Elute Plexa, Bond Elute Plexa PAX, Bond Elute PlexaPCX, and SupelMIP sorbents, were investigated. The present study was focused on the retention and elution of pharmaceutically active substances based on several analyte-sorbent interaction properties. Basic drugs, such as beta-blockers (i.e., atenolol,pindolol, acebutolol, metoprolol, labetalol, and propranolol) were selected as the model compounds for this study. These compounds are frequently encountered in anti-doping tests. The extraction efficiencies of the individual sorbents were compared basedon the recovery of known amounts of the targeted analytes in a metered elution volume (500 mu L) in three separate elution fractions. The elution efficiency of the total amount of the target analytes on various sorbents was not appreciab

Název v anglickém jazyce

Retention and selectivity of basic drugs on solid-phase extraction sorbents: Application to direct determination of beta-blockers in urine

Popis výsledku anglicky

Seven solid phase sorbent materials with reversed-phase, mixed-mode interactions (ion-exchange and reversed-phase), and molecularly imprinted polymers (MIP), namely Oasis HLB, Oasis MAX, Oasis MCX, Bond Elute Plexa, Bond Elute Plexa PAX, Bond Elute PlexaPCX, and SupelMIP sorbents, were investigated. The present study was focused on the retention and elution of pharmaceutically active substances based on several analyte-sorbent interaction properties. Basic drugs, such as beta-blockers (i.e., atenolol,pindolol, acebutolol, metoprolol, labetalol, and propranolol) were selected as the model compounds for this study. These compounds are frequently encountered in anti-doping tests. The extraction efficiencies of the individual sorbents were compared basedon the recovery of known amounts of the targeted analytes in a metered elution volume (500 mu L) in three separate elution fractions. The elution efficiency of the total amount of the target analytes on various sorbents was not appreciab

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

<a href="/cs/project/EE2.3.30.0061" target="_blank" >EE2.3.30.0061: Zvýšení kapacity vědecko-výzkumných týmů Univerzity Karlovy prostřednictvím nových pozic pro absolventy doktorandských studií</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Analytical and Bioanalytical Chemistry

ISSN

1618-2642

e-ISSN

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Svazek periodika

406

Číslo periodika v rámci svazku

17

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

9

Strana od-do

4207-4215

Kód UT WoS článku

000337787400017

EID výsledku v databázi Scopus

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