In vitro functional interactions of acetylcholine esterase inhibitors and muscarinic receptor antagonists in the urinary bladder of the rat

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F14%3A10282160" target="_blank" >RIV/00216208:11160/14:10282160 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/14:10282160 RIV/60162694:G44__/14:43875049

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1111/1440-1681.12191/full" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/1440-1681.12191/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/1440-1681.12191" target="_blank" >10.1111/1440-1681.12191</a>

Jazyk výsledku

angličtina

Název v původním jazyce

In vitro functional interactions of acetylcholine esterase inhibitors and muscarinic receptor antagonists in the urinary bladder of the rat

Popis výsledku v původním jazyce

1. Obidoxime, a weak acetylcholine-esterase (AChE) inhibitor, exerts muscarinic receptor antagonism with a significant muscarinic M2 receptor selective profile. 2. The current examinations aimed to determine the functional significance of muscarinic M2 receptors in the state of AChE inhibition, elucidating muscarinic M2 and M3 receptor interaction. 3. In the in vitro examinations, methacholine evoked concentration- dependent bladder contractile and atrial frequency inhibitory responses. Although atropine abolished both, methoctramine (1 mu mol/L) only affected the cholinergic response in the atrial preparations. 4. However, in the presence of methoctramine, physostigmine, an AChE inhibitor, increased the basal tension of the bladder strip preparations(+68%), as well as the contractile responses to low concentrations of methacholine (< 5 mu mol/L; + 90-290%). In contrast to physostigmine, obidoxime alone raised the basal tension (+58%) and the responses to low concentrations of methach

Název v anglickém jazyce

In vitro functional interactions of acetylcholine esterase inhibitors and muscarinic receptor antagonists in the urinary bladder of the rat

Popis výsledku anglicky

1. Obidoxime, a weak acetylcholine-esterase (AChE) inhibitor, exerts muscarinic receptor antagonism with a significant muscarinic M2 receptor selective profile. 2. The current examinations aimed to determine the functional significance of muscarinic M2 receptors in the state of AChE inhibition, elucidating muscarinic M2 and M3 receptor interaction. 3. In the in vitro examinations, methacholine evoked concentration- dependent bladder contractile and atrial frequency inhibitory responses. Although atropine abolished both, methoctramine (1 mu mol/L) only affected the cholinergic response in the atrial preparations. 4. However, in the presence of methoctramine, physostigmine, an AChE inhibitor, increased the basal tension of the bladder strip preparations(+68%), as well as the contractile responses to low concentrations of methacholine (< 5 mu mol/L; + 90-290%). In contrast to physostigmine, obidoxime alone raised the basal tension (+58%) and the responses to low concentrations of methach

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical and Experimental Pharmacology and Physiology

ISSN

1440-1681

e-ISSN

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Svazek periodika

41

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

PK - Pákistánská islámská republika

Počet stran výsledku

8

Strana od-do

139-146

Kód UT WoS článku

000343904500006

EID výsledku v databázi Scopus

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