5-Bromo- and 3,5-dibromo-2-hydroxy-N-phenylbenzamides - inhibitors of photosynthesis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F14%3A10293795" target="_blank" >RIV/00216208:11160/14:10293795 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.degruyter.com/view/j/chempap.2014.68.issue-1/s11696-013-0416-7/s11696-013-0416-7.xml" target="_blank" >http://www.degruyter.com/view/j/chempap.2014.68.issue-1/s11696-013-0416-7/s11696-013-0416-7.xml</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/s11696-013-0416-7" target="_blank" >10.2478/s11696-013-0416-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

5-Bromo- and 3,5-dibromo-2-hydroxy-N-phenylbenzamides - inhibitors of photosynthesis

Popis výsledku v původním jazyce

5-Bromo-(Br-PBA) and 3,5-dibromo-2-hydroxy-N-phenylbenzamides (Br-2-PBA) inhibited photosynthetic electron transport (PET) and their inhibitory efficiency depended on the compound lipophilicity as well as on the electronic properties of the R substituentin the N-phenyl moiety. Br-PBA showed higher PET inhibiting activity than Br-2-PBA with the same R substituent. The most effective inhibitors in the tested series were the derivatives with R = 3-F (Br-PBA; IC50 = 4.3 mu mol dm(-3)) and R = 3-Cl (Br-2-PBA; IC50 = 8.6 mu mol dm(-3)). Bilinear dependence of the PET inhibiting activity on the lipophilicity of the compounds as well as on the Hammett constant, sigma, of the R substituent was observed for both investigated series. Using EPR spectroscopy it was found that the site of action of the tested compounds in the photosynthetic apparatus is situated on the donor side of PS 2, in D. or in the Z./D. intermediates. Interaction of the studied compounds with chlorophyll a and aromatic amino

Název v anglickém jazyce

5-Bromo- and 3,5-dibromo-2-hydroxy-N-phenylbenzamides - inhibitors of photosynthesis

Popis výsledku anglicky

5-Bromo-(Br-PBA) and 3,5-dibromo-2-hydroxy-N-phenylbenzamides (Br-2-PBA) inhibited photosynthetic electron transport (PET) and their inhibitory efficiency depended on the compound lipophilicity as well as on the electronic properties of the R substituentin the N-phenyl moiety. Br-PBA showed higher PET inhibiting activity than Br-2-PBA with the same R substituent. The most effective inhibitors in the tested series were the derivatives with R = 3-F (Br-PBA; IC50 = 4.3 mu mol dm(-3)) and R = 3-Cl (Br-2-PBA; IC50 = 8.6 mu mol dm(-3)). Bilinear dependence of the PET inhibiting activity on the lipophilicity of the compounds as well as on the Hammett constant, sigma, of the R substituent was observed for both investigated series. Using EPR spectroscopy it was found that the site of action of the tested compounds in the photosynthetic apparatus is situated on the donor side of PS 2, in D. or in the Z./D. intermediates. Interaction of the studied compounds with chlorophyll a and aromatic amino

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemical Papers

ISSN

0366-6352

e-ISSN

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Svazek periodika

68

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

7

Strana od-do

46-52

Kód UT WoS článku

000324491200006

EID výsledku v databázi Scopus

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